{"id":"W4399764294","doi":"10.1016/j.celrep.2024.114370","title":"A pre-vaccination immune metabolic interplay determines the protective antibody response to a dengue virus vaccine","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Vir Biotechnology; Instituto Butantan; GlaxoSmithKline","keywords":"Virology; Dengue virus; Dengue fever; Vaccination; Dengue vaccine; Immune system; Virus; Antibody response; Antibody; Antibody-dependent enhancement; Immunology; Biology; Original antigenic sin; Medicine; Influenza A virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574193,0.0001703459,0.0002064656,0.0001650146,0.000126797,0.0004296848,0.00007812906,0.0001991436,0.001420196],"category_scores_gemma":[0.0001973201,0.000152377,0.0001246169,0.00008420608,0.0001441038,0.0002812564,0.0002407581,0.0004509788,0.0002915618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123311,"about_ca_system_score_gemma":0.0002102174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002671141,"about_ca_topic_score_gemma":0.0004997303,"domain_scores_codex":[0.9998696,0.00002406006,0.000007209922,0.00002632972,0.00001856169,0.00005428994],"domain_scores_gemma":[0.9998986,0.00001551385,0.00002527847,0.000009222882,0.00001761431,0.00003376848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003252131,0.0000456807,0.006928613,0.00002854223,0.000007443897,0.0000571066,0.00002911464,0.00007536892,0.9884052,0.0001568784,0.00003878073,0.003902102],"study_design_scores_gemma":[0.00003706407,0.001583097,0.3999254,0.00003684704,0.00007423827,0.001119861,0.0005573592,0.002700568,0.5884852,0.0007572609,0.004708721,0.00001439807],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970465,0.0007940308,0.0008604784,0.00007849279,0.00001262501,0.00001315065,0.0001066385,0.00001243836,0.001075652],"genre_scores_gemma":[0.9981474,0.0004139366,0.0005065052,0.00005533355,0.000009372098,0.00001006255,0.0001129465,0.000003523467,0.0007409063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420196,"threshold_uncertainty_score":0.004751027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00549395995481524,"score_gpt":0.3036251637194311,"score_spread":0.2981312037646159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}