{"id":"W4399766039","doi":"10.32920/26052796.v1","title":"The Synthesis of Novel Triazole Based MRCK Inhibitors","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; Sciencetech (Canada)","funders":"","keywords":"Triazole; Chemistry; Computer science; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527222,0.0004093122,0.00031602,0.000289876,0.0001757163,0.0002096085,0.0003972781,0.0003331066,0.004367383],"category_scores_gemma":[0.0001509327,0.0001477657,0.0002969526,0.0003268135,0.0001586442,0.0003586109,0.0002560338,0.0007603922,0.001717607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004287116,"about_ca_system_score_gemma":0.0003654443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005647086,"about_ca_topic_score_gemma":0.001412055,"domain_scores_codex":[0.9998996,0.00001064038,0.000009563913,0.00002230014,0.00002865011,0.00002929962],"domain_scores_gemma":[0.9999621,0.000004841293,0.000009726644,0.000004724384,0.000008569501,0.000009930372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002195216,0.0001492823,0.000106606,0.001083968,0.0000454338,0.0005654026,0.0001418563,0.002665283,0.9570392,0.006596925,0.002568244,0.02881838],"study_design_scores_gemma":[0.0001674809,0.001673005,0.0009866757,0.00009003434,0.00006816401,0.0008999688,0.00004149639,0.003113297,0.9286065,0.001151819,0.06313951,0.00006194618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7117738,0.04905122,0.1358225,0.001942501,0.0009441118,0.001318069,0.008829002,0.001917879,0.0884009],"genre_scores_gemma":[0.9140448,0.02457045,0.03749874,0.0005190034,0.00008567301,0.0004310418,0.002773418,0.0001084131,0.01996855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004367383,"threshold_uncertainty_score":0.01461035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03683015812880375,"score_gpt":0.2587351589899542,"score_spread":0.2219050008611504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}