{"id":"W4399766048","doi":"10.32920/26052790","title":"Synthesis of Diazaspirocycles for MRCK Inhibitors as Anti-cancer Agents","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Cancer; Pharmacology; Chemistry; Cancer research; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003227041,0.0004467636,0.0003661495,0.0004338754,0.0001809922,0.0002672282,0.0004883215,0.0004499836,0.007232192],"category_scores_gemma":[0.0002825971,0.0002012621,0.0003696308,0.0003164538,0.0001736261,0.0004223697,0.0004284224,0.0007265443,0.004348662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000365637,"about_ca_system_score_gemma":0.0004577684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002609155,"about_ca_topic_score_gemma":0.0006364372,"domain_scores_codex":[0.9998363,0.00002872649,0.00001556313,0.00003187478,0.00004999683,0.00003752827],"domain_scores_gemma":[0.9999356,0.00000875488,0.00001199836,0.000009205087,0.00001542221,0.00001896374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003616288,0.000300324,0.0001920876,0.001470744,0.00006374798,0.001148729,0.0002263576,0.004837077,0.8939962,0.02629147,0.00519443,0.06591728],"study_design_scores_gemma":[0.0003342937,0.002292205,0.001124065,0.0001858819,0.00006339869,0.001014659,0.00006443664,0.004285302,0.8026133,0.006154994,0.1817776,0.00008976916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5529693,0.04059158,0.1680048,0.002369603,0.001715356,0.002466259,0.008250973,0.001600728,0.2220314],"genre_scores_gemma":[0.8439273,0.03098584,0.07937594,0.0008628321,0.0002426292,0.000831834,0.003144615,0.0002997551,0.04032921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007232192,"threshold_uncertainty_score":0.02419406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06794963195500404,"score_gpt":0.3461603018725853,"score_spread":0.2782106699175813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}