{"id":"W4399767204","doi":"10.1126/scisignal.adi8743","title":"Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery","year":2024,"lang":"en","type":"review","venue":"Science Signaling","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute on Aging; National Institutes of Health","keywords":"PIN1; Phosphorylation; Prolyl isomerase; Signal transduction; Kinase; Drug discovery; Peptidylprolyl isomerase; FKBP; Biology; Phosphatase; Cell biology; Isomerase; Cancer research; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001604421,0.0004689198,0.0005765714,0.0003247979,0.0001804138,0.0004607962,0.0004514823,0.0002066615,0.00003796189],"category_scores_gemma":[0.0001993736,0.0004080656,0.0002758004,0.0007969538,0.000489209,0.00005688144,0.0003936196,0.0003106861,0.00003577765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557569,"about_ca_system_score_gemma":0.001176323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001028557,"about_ca_topic_score_gemma":0.000005113244,"domain_scores_codex":[0.9970079,0.00009853335,0.0008486792,0.001017861,0.0005706489,0.000456393],"domain_scores_gemma":[0.9988774,0.0000646398,0.0003358032,0.0004383394,0.0001148896,0.0001689109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008147451,0.0008718523,0.001195742,0.1003548,0.0006274574,0.000395902,0.005478325,0.005733008,0.4677472,0.001956677,0.0009324562,0.4138918],"study_design_scores_gemma":[0.004257845,0.0004377932,0.0004646809,0.09713668,0.004651958,0.0004127726,0.001222506,0.007522103,0.4712219,0.005715613,0.395708,0.01124815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.06728244,0.9307392,0.0005648375,0.00001480437,0.0003808966,0.0006220256,0.0001222197,0.00002962813,0.000243933],"genre_scores_gemma":[0.7702727,0.2266849,0.0008401682,0.0000470131,0.0005445072,0.0002904014,0.0007539277,0.00009130131,0.0004750537],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7040543,"threshold_uncertainty_score":0.9998371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613727974600732,"score_gpt":0.2831191260708198,"score_spread":0.2669818463248125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}