{"id":"W4399775645","doi":"10.1186/s12885-024-12505-1","title":"Oral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer","year":2024,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Fudan University; Prostate Cancer Canada; Movember Foundation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Prostate Cancer Foundation","keywords":"Prostate cancer; Pathology; Clinical significance; Medicine; Comedo; DNA methylation; Prostatectomy; Surgical oncology; Epigenetics; Prostate; Cancer; Biomarker; Hypoxia (environmental); Tumor hypoxia; Carcinoma; Oncology; Breast cancer; Internal medicine; Biology; Ductal carcinoma; Radiation therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009965966,0.0001700781,0.000256702,0.0002444425,0.0001259279,0.0002547119,0.00009612551,0.0001311254,0.001292105],"category_scores_gemma":[0.000237518,0.00009183612,0.0001503552,0.000262817,0.0001713729,0.0001143097,0.0001321928,0.0002605687,0.0001486282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000220476,"about_ca_system_score_gemma":0.0001665948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006502548,"about_ca_topic_score_gemma":0.001699216,"domain_scores_codex":[0.9999295,0.00001329151,0.000003465218,0.00002067868,0.0000216078,0.00001147673],"domain_scores_gemma":[0.99989,0.0000149705,0.00005217913,0.000008067696,0.00001128218,0.00002343319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004325949,0.0001857527,0.2388085,0.0003461498,0.0001446191,0.0005299257,0.0001302617,0.0007039146,0.6977775,0.00007871882,0.0005277772,0.05644092],"study_design_scores_gemma":[0.00006405373,0.002335921,0.9170865,0.00002251733,0.0002271712,0.00188784,0.0001657,0.001722446,0.07369957,0.000138822,0.002627563,0.00002190063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964488,0.001694518,0.0007541157,0.00005387436,0.000005856168,0.00002693003,0.0004038435,0.00002771364,0.000584388],"genre_scores_gemma":[0.9988727,0.0003516595,0.0002949272,0.00002405571,0.000006352063,0.00001198618,0.0002259644,0.000003465309,0.0002090296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292105,"threshold_uncertainty_score":0.004322529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722836249259583,"score_gpt":0.3144155002734825,"score_spread":0.2971871377808867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}