{"id":"W4399783208","doi":"10.1021/jacs.4c03196","title":"The Human Ganglioside Interactome in Live Cells Revealed Using Clickable Photoaffinity Ganglioside Probes","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Office of the Director; University of California, Davis; Shanghai Jiao Tong University; National Cancer Institute; National Institutes of Health; University of Alberta; National Institute of General Medical Sciences; University of St Andrews; Johns Hopkins University","keywords":"Interactome; Ganglioside; Chemistry; Glycan; Biochemistry; Cell biology; Click chemistry; Transmembrane protein; Cell adhesion; Cell; Glycoprotein; Receptor; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771702,0.0003026143,0.0002158893,0.0002817076,0.0002052077,0.0002796009,0.0001969502,0.0004027238,0.001266338],"category_scores_gemma":[0.00009770059,0.0001760577,0.0002020886,0.000238724,0.000168187,0.000251932,0.0002297771,0.0004454455,0.0005641607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002725046,"about_ca_system_score_gemma":0.0001693713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115914,"about_ca_topic_score_gemma":0.001701384,"domain_scores_codex":[0.9998678,0.00001537675,0.000005461917,0.00005022427,0.00002975735,0.00003132851],"domain_scores_gemma":[0.9999484,0.00001937754,0.000008627481,0.000006034083,0.000009453636,0.000008234874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002339679,0.000004348322,0.0000926251,0.00001345909,0.000002758711,0.00003343876,0.00001462687,0.00002208344,0.9991991,0.00006519147,0.00003313815,0.0004958442],"study_design_scores_gemma":[0.000004401268,0.0000535549,0.002665362,0.000003333544,0.00001234246,0.0001523238,0.00003433065,0.001343454,0.9941601,0.00008193763,0.001483056,0.000005828731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573511,0.002404634,0.0328421,0.0003295812,0.00004412186,0.00004873218,0.00114235,0.0002776828,0.005559716],"genre_scores_gemma":[0.9628925,0.002786324,0.02591879,0.0003442588,0.00002982304,0.0001409994,0.001511595,0.00006726202,0.006308365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266338,"threshold_uncertainty_score":0.004236281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570364433552239,"score_gpt":0.3132825538696082,"score_spread":0.2975789095340858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}