{"id":"W4399783760","doi":"10.1093/neuonc/noae064.457","title":"MDB-08. MYC AND TGFΒ PROMOTE GROUP 3 MEDULLOBLASTOMA TUMOR RESISTANCE THROUGH DEREGULATION OF POLYCOMB TARGETS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Medulloblastoma; Deregulation; Polycomb-group proteins; Cancer research; Transforming growth factor; Cell biology; Medicine; Biology; Gene; Repressor; Genetics; Market economy; Transcription factor; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008373533,0.0001867509,0.0001848831,0.0002131486,0.000110903,0.000251488,0.0001281767,0.0001852618,0.002587486],"category_scores_gemma":[0.00006357903,0.0001004816,0.0002434609,0.0001295726,0.0001543916,0.00009034946,0.0001735966,0.0006567007,0.0005631448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091537,"about_ca_system_score_gemma":0.0001590121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006649047,"about_ca_topic_score_gemma":0.001289177,"domain_scores_codex":[0.9998934,0.000009983986,0.00000842235,0.00001772277,0.00003915205,0.00003132032],"domain_scores_gemma":[0.9999297,0.000009327387,0.00002074734,0.000006896395,0.000006083981,0.00002728415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619075,0.00006365929,0.0007442827,0.00003159256,0.000007290285,0.00003651259,0.00001368671,0.00006665998,0.9968047,0.00008044096,0.0001528577,0.001836386],"study_design_scores_gemma":[0.00005637192,0.0007572985,0.02311522,0.000009782359,0.00003048043,0.0003282256,0.00009253615,0.001627886,0.9659072,0.00008740693,0.007981781,0.000005718311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993413,0.001354529,0.001395642,0.000204249,0.00003865387,0.00004822439,0.001278402,0.0001431288,0.002124153],"genre_scores_gemma":[0.9939329,0.0004871473,0.0008401213,0.0001091707,0.000005593519,0.00004513946,0.001177435,0.00002565306,0.003376807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002587486,"threshold_uncertainty_score":0.008656025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01444555046815065,"score_gpt":0.2889429060759818,"score_spread":0.2744973556078312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}