{"id":"W4399785658","doi":"10.1093/neuonc/noae064.402","title":"LGG-09. REBOUND GROWTH AFTER MAPKI WITHDRAWAL INVOLVES RAPID MAPK REACTIVATION AND CYTOKINE-MEDIATED MICROGLIA RECRUITMENT IN PEDIATRIC LOW-GRADE GLIOMA MODEL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brain Tumour Research; Universitätsklinikum Heidelberg; Hospital for Sick Children; Murdoch Children's Research Institute; McGill University Health Centre; Deutsches Krebsforschungszentrum; Broad Institute; Brigham and Women's Hospital; McGill University; Deutschen Konsortium für Translationale Krebsforschung; Children’s Hospital of Wisconsin Research Institute","keywords":"Microglia; MAPK/ERK pathway; Glioma; Cytokine; Medicine; Cancer research; Immunology; Biology; Signal transduction; Cell biology; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410626,0.0005086202,0.0004954039,0.0003294472,0.0001915365,0.0004210917,0.0003026094,0.0004696953,0.001890728],"category_scores_gemma":[0.0001586225,0.0001639514,0.0004529583,0.0002815279,0.000210522,0.0002060265,0.0002015548,0.001282664,0.0009129155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004691037,"about_ca_system_score_gemma":0.0005186143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002376746,"about_ca_topic_score_gemma":0.003655764,"domain_scores_codex":[0.9997594,0.00002435339,0.00001561533,0.00005010936,0.00008453645,0.00006608257],"domain_scores_gemma":[0.9998773,0.00001409305,0.00002721209,0.00001755133,0.00002087506,0.0000429375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001620237,0.0007268229,0.002663211,0.000364127,0.00006012288,0.000482193,0.00009863325,0.001296841,0.978392,0.0002080969,0.003408905,0.01067884],"study_design_scores_gemma":[0.0001837219,0.00532705,0.01859746,0.00005722014,0.0001306199,0.00129106,0.0002000292,0.005530894,0.950819,0.0002560509,0.01757283,0.00003414822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809584,0.002564083,0.003481602,0.0003276844,0.0001146579,0.0002622503,0.008726891,0.0005312767,0.003033198],"genre_scores_gemma":[0.9687167,0.001979769,0.005976967,0.0004844553,0.00001477287,0.0006734121,0.01716122,0.00009920418,0.004893559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002376746,"threshold_uncertainty_score":0.006325066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896078953569396,"score_gpt":0.2913320260027335,"score_spread":0.2623712364670395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}