{"id":"W4399785658","doi":"10.1093/neuonc/noae064.402","title":"LGG-09. REBOUND GROWTH AFTER MAPKI WITHDRAWAL INVOLVES RAPID MAPK REACTIVATION AND CYTOKINE-MEDIATED MICROGLIA RECRUITMENT IN PEDIATRIC LOW-GRADE GLIOMA MODEL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brain Tumour Research; Universitätsklinikum Heidelberg; Hospital for Sick Children; Murdoch Children's Research Institute; McGill University Health Centre; Deutsches Krebsforschungszentrum; Broad Institute; Brigham and Women's Hospital; McGill University; Deutschen Konsortium für Translationale Krebsforschung; Children’s Hospital of Wisconsin Research Institute","keywords":"Microglia; MAPK/ERK pathway; Glioma; Cytokine; Medicine; Cancer research; Immunology; Biology; Signal transduction; Cell biology; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002464884,0.0003853071,0.0005956826,0.0008748977,0.00006216708,0.00006908012,0.00009076282,0.0003397266,0.00004406136],"category_scores_gemma":[0.0001480455,0.0003250544,0.000117319,0.0007620151,0.0001176466,0.0002094813,0.0001065485,0.0004743697,0.00006391593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005768716,"about_ca_system_score_gemma":0.0003824445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007742259,"about_ca_topic_score_gemma":0.0001118876,"domain_scores_codex":[0.9976257,0.0001632329,0.0005682459,0.0008259644,0.0003036463,0.0005132037],"domain_scores_gemma":[0.9987098,0.0005178025,0.0001212289,0.0003113068,0.00008702303,0.0002528645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001481104,0.002602276,0.1000737,0.0006778076,0.0002061423,0.01181984,0.001990978,0.00002039504,0.8641713,0.0004290013,0.006650177,0.0098773],"study_design_scores_gemma":[0.03942556,0.01316442,0.3804249,0.001031759,0.002951442,0.003722327,0.0006451476,0.02192034,0.4528259,0.004604461,0.07692844,0.00235535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878165,0.003271229,0.00001554539,0.006192407,0.0005407773,0.001502251,0.00005583296,0.0001526082,0.0004529072],"genre_scores_gemma":[0.9943586,0.002427549,0.0004635273,0.001186346,0.0003700849,0.0009578354,0.0001352839,0.00007499276,0.00002576409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4113454,"threshold_uncertainty_score":0.9999201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896078953569396,"score_gpt":0.2913320260027335,"score_spread":0.2623712364670395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}