{"id":"W4399786010","doi":"10.1093/neuonc/noae064.431","title":"LGG-40. TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY PEDIATRIC LOW-GRADE GLIOMA (PLGG): REVERSIBLE DECREASES IN GROWTH VELOCITY IN THE PHASE 2 FIREFLY-1 TRIAL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université Laval","funders":"University of California, San Francisco; Medical School, University of Michigan; Université de Montréal; Rigshospitalet; Humboldt-Universität zu Berlin; Centre Hospitalier Universitaire de Québec; Great Ormond Street Institute of Child Health; Great Ormond Street Hospital for Children; Tel Aviv University; Seoul National University; College of Medicine, Seoul National University; Gentofte Hospital; Yonsei University; Newcastle University; Cancer Research Institute; Texas Children's Hospital; McGill University; McGill University Health Centre; Deutsches Krebsforschungszentrum; Freie Universität Berlin; Université Laval","keywords":"Refractory (planetary science); Glioma; Internal medicine; Medicine; Firefly protocol; Gastroenterology; Oncology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005464481,0.0005085788,0.0006665673,0.0001748425,0.0001522594,0.0005736317,0.0003249156,0.0003741218,0.003162347],"category_scores_gemma":[0.0004506202,0.0001484471,0.000763156,0.0001887836,0.0002546141,0.0003146695,0.000201165,0.001239308,0.0004892964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007115211,"about_ca_system_score_gemma":0.0007644733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001763,"about_ca_topic_score_gemma":0.004717243,"domain_scores_codex":[0.9998265,0.00007184507,0.000009768307,0.00002573712,0.00002573233,0.00004046781],"domain_scores_gemma":[0.9998443,0.00002565929,0.00003398555,0.00001164779,0.000009892397,0.00007453596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4842274,0.008654389,0.01160534,0.003775502,0.00338588,0.0007380343,0.0004577095,0.004762,0.03718349,0.001354657,0.02061773,0.4232379],"study_design_scores_gemma":[0.6602889,0.2606508,0.03715291,0.0004835072,0.002015129,0.002081509,0.0002499067,0.003633099,0.01210858,0.001324003,0.01995059,0.00006089889],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871643,0.006040004,0.0002801296,0.0006194967,0.0001132824,0.0003933755,0.00116491,0.0001286223,0.004095941],"genre_scores_gemma":[0.9928206,0.002339954,0.0005372372,0.0004608586,0.0000556349,0.0003813452,0.001357104,0.00001757513,0.002029708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003162347,"threshold_uncertainty_score":0.01057911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920981703444509,"score_gpt":0.3246425832411657,"score_spread":0.2954327662067206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}