{"id":"W4399786324","doi":"10.1093/neuonc/noae064.286","title":"HGG-02. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PEDIATRIC PATIENTS WITH TRK FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); BC Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Central nervous system; Term (time); Oncology; Neuroscience; Internal medicine; Psychology; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003764214,0.0004934429,0.001273365,0.001187127,0.0001464574,0.001092812,0.0006500866,0.0004275953,0.001963975],"category_scores_gemma":[0.002901901,0.0002197392,0.00186207,0.002109613,0.0002906891,0.0006731584,0.0004168567,0.0007035449,0.0005205284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009839634,"about_ca_system_score_gemma":0.0009230724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002420001,"about_ca_topic_score_gemma":0.00498939,"domain_scores_codex":[0.9985214,0.0005433872,0.0001564909,0.0002321645,0.0004236753,0.0001228706],"domain_scores_gemma":[0.9963402,0.001165576,0.001604482,0.0001746664,0.0004601091,0.0002549416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02726777,0.0003288742,0.6758692,0.004797635,0.01338948,0.0005785995,0.0002444044,0.002649027,0.005583756,0.0003094518,0.0211714,0.2478104],"study_design_scores_gemma":[0.00481489,0.005519319,0.9445091,0.0005447408,0.01144471,0.001538524,0.0001025424,0.001207905,0.002136931,0.0001901789,0.02793784,0.00005327409],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8475526,0.08769315,0.001404596,0.0009255568,0.00008037669,0.0008396317,0.05128919,0.0002567067,0.009958153],"genre_scores_gemma":[0.935699,0.01679373,0.001792456,0.001262786,0.000187767,0.0005058752,0.04220835,0.00007948196,0.001470546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003764214,"threshold_uncertainty_score":0.0199073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008770957790696442,"score_gpt":0.2604579846732377,"score_spread":0.2516870268825413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}