{"id":"W4399786324","doi":"10.1093/neuonc/noae064.286","title":"HGG-02. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PEDIATRIC PATIENTS WITH TRK FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); BC Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Central nervous system; Term (time); Oncology; Neuroscience; Internal medicine; Psychology; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140395,0.0002364317,0.0007945419,0.0006665651,0.00004683064,0.00002011782,0.00007897448,0.000144049,0.00004614223],"category_scores_gemma":[0.00002717813,0.0001719435,0.0001010902,0.001273306,0.00005385676,0.00008930046,0.0000652868,0.0002361072,0.000005720436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000342361,"about_ca_system_score_gemma":0.0002009866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008242845,"about_ca_topic_score_gemma":0.0002047142,"domain_scores_codex":[0.998059,0.0002493071,0.0005174166,0.0005581162,0.0002622432,0.0003539012],"domain_scores_gemma":[0.9989935,0.0002434006,0.0001589564,0.0002993344,0.00008372798,0.0002210689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00137315,0.002087601,0.9726017,0.0003204336,0.000290301,0.002112042,0.0003696142,0.00008915902,0.001600423,0.000014266,0.00007507673,0.01906623],"study_design_scores_gemma":[0.006280031,0.00334797,0.9868422,0.0001048297,0.002345087,0.00007231274,0.00003860967,0.0002730424,0.0004277644,5.019599e-7,0.0001396884,0.0001279373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978122,0.0004414649,0.000007546494,0.0001810733,0.0002154514,0.0009414972,0.00004322228,0.00009137716,0.0002661587],"genre_scores_gemma":[0.9990379,0.0001151844,0.0000635482,0.00009676474,0.0001079849,0.00003837085,0.0005039679,0.00003254509,0.000003695556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01893829,"threshold_uncertainty_score":0.7011653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008770957790696442,"score_gpt":0.2604579846732377,"score_spread":0.2516870268825413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}