{"id":"W4399786851","doi":"10.1093/neuonc/noae064.498","title":"MDB-49. OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Sonic hedgehog; Medulloblastoma; Medicine; Protocol (science); Oncology; Internal medicine; Pediatrics; Pathology; Biology; Genetics; Gene; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739368,0.0002795003,0.0003831401,0.0001727106,0.00004892912,0.00001846931,0.0001906683,0.0002015549,0.00001404656],"category_scores_gemma":[0.0001513983,0.0002056918,0.00007672478,0.0001858348,0.0002129932,0.000006888789,0.0001059196,0.0002811585,0.000006706185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007387355,"about_ca_system_score_gemma":0.0001869686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007973016,"about_ca_topic_score_gemma":0.0003276443,"domain_scores_codex":[0.9983839,0.0001937154,0.0003231866,0.0006610298,0.0001749642,0.0002632194],"domain_scores_gemma":[0.999333,0.0001136388,0.0001506589,0.0002300974,0.0001115181,0.0000611306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005232546,0.0007294615,0.6964429,0.00003819135,0.000844562,0.0000951558,0.0009107232,0.00009106409,0.2663402,0.00007772833,0.0004133895,0.02878405],"study_design_scores_gemma":[0.009298636,0.01351511,0.6746002,0.0001268615,0.00004645272,0.0001283695,0.0001344139,0.0002839909,0.2897456,0.00005721419,0.01165255,0.0004105793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867542,0.000141796,0.00001856446,0.0003258646,0.00009305398,0.01194274,0.00007507351,0.0000463843,0.0006023207],"genre_scores_gemma":[0.9908051,0.0001432079,0.0001275955,0.0001843453,0.0001042373,0.008516098,0.00003075361,0.00004420756,0.00004438363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02837347,"threshold_uncertainty_score":0.838787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008117846420133063,"score_gpt":0.2833669149260139,"score_spread":0.2752490685058808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}