{"id":"W4399787174","doi":"10.1093/neuonc/noae064.145","title":"DIPG-92. IMMUNE ACTIVATION STUDIES WITH THE NEOANTIGEN-BASED PEPTIDE VACCINE RHSC-DIPGVAX DEMONSTRATE ANTIBODY-MEDIATED RESPONSES AND EPITOPE SPREADING IN PEDIATRIC PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Epitope; Medicine; Antibody; Immune escape; Immune system; Peptide; Cancer research; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529835,0.0001802061,0.0001849853,0.0001020627,0.00006248021,0.0001048896,0.00007467021,0.0001604001,0.001079001],"category_scores_gemma":[0.0001266177,0.00005904126,0.0001322171,0.00008031767,0.0001157849,0.0001089615,0.000092466,0.0003475657,0.0001809089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162512,"about_ca_system_score_gemma":0.00009925442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003923751,"about_ca_topic_score_gemma":0.0004672561,"domain_scores_codex":[0.9999267,0.00001527769,0.000004095564,0.00001925971,0.00001166704,0.00002300287],"domain_scores_gemma":[0.9999374,0.00001636905,0.00001133165,0.000005366781,0.000006785949,0.00002274404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004265453,0.0009270046,0.01693941,0.0001876779,0.00005715594,0.0008445171,0.0001188425,0.000534371,0.9512869,0.000109102,0.0005044116,0.02422539],"study_design_scores_gemma":[0.001125954,0.08273427,0.3167213,0.0000273513,0.0001820582,0.009679034,0.0002392168,0.00338118,0.5769228,0.0001435053,0.008830053,0.00001316914],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988685,0.0003123925,0.0002010466,0.00002074051,0.000005457103,0.00002824036,0.0001158964,0.00001160619,0.0004361837],"genre_scores_gemma":[0.9989527,0.0001243666,0.0001931639,0.00002449087,0.000003446168,0.00001698704,0.0003804261,0.000001922036,0.0003023468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079001,"threshold_uncertainty_score":0.003609598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067760045037977,"score_gpt":0.2660334497900703,"score_spread":0.2553558493396905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}