{"id":"W4399787342","doi":"10.1093/neuonc/noae064.295","title":"HGG-11. TRANS-SPECIES STUDY OF IDH-MUTANT REPLICATION-REPAIR DEFICIENT HIGH-GRADE GLIOMAS (RRD-HGG) AND RESPONSE TO COMBINED TARGETED AND IMMUNOTHERAPY: AN IRRDC STUDY","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Mutant; Immunotherapy; Replication (statistics); Cancer research; Biology; Virology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004889395,0.0004931039,0.0004723222,0.0006466192,0.0002133574,0.0003126933,0.0003869802,0.000420511,0.001636034],"category_scores_gemma":[0.000170517,0.0002044416,0.0004683241,0.000408795,0.0003956557,0.0002099299,0.0002814651,0.0006570785,0.000561616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181409,"about_ca_system_score_gemma":0.000213486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111263,"about_ca_topic_score_gemma":0.001003695,"domain_scores_codex":[0.9996998,0.00007165698,0.00001935782,0.00009054421,0.00005039973,0.00006824326],"domain_scores_gemma":[0.9996823,0.00003543618,0.00006894495,0.00006935752,0.00002749364,0.0001163864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008490373,0.003065776,0.03369768,0.0002001888,0.0001597564,0.0015601,0.0001860478,0.0003885768,0.9411455,0.000207534,0.0003534609,0.01054497],"study_design_scores_gemma":[0.001100707,0.08051585,0.4619502,0.00003554597,0.0005958399,0.01601341,0.0007111107,0.002326456,0.4268748,0.0002173804,0.009609181,0.00004955528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973915,0.0005565697,0.000369693,0.00002401655,0.000007065177,0.00009060209,0.0009159056,0.00002840207,0.0006162702],"genre_scores_gemma":[0.9947079,0.0004430527,0.0007440705,0.00005451063,0.000008911159,0.00007326742,0.002523082,0.00002470461,0.001420409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001636034,"threshold_uncertainty_score":0.005473077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274797807977747,"score_gpt":0.3212379657217738,"score_spread":0.2937581849239991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}