{"id":"W4399787342","doi":"10.1093/neuonc/noae064.295","title":"HGG-11. TRANS-SPECIES STUDY OF IDH-MUTANT REPLICATION-REPAIR DEFICIENT HIGH-GRADE GLIOMAS (RRD-HGG) AND RESPONSE TO COMBINED TARGETED AND IMMUNOTHERAPY: AN IRRDC STUDY","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Mutant; Immunotherapy; Replication (statistics); Cancer research; Biology; Virology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007722182,0.0003171839,0.000771069,0.0005262019,0.0001498889,0.00004424194,0.0001283496,0.0001210273,0.00005282783],"category_scores_gemma":[0.0001724782,0.0002539734,0.00008823441,0.0006688134,0.0001356765,0.00006976305,0.00007809047,0.0001983691,0.000005495637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910426,"about_ca_system_score_gemma":0.0001669243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002935412,"about_ca_topic_score_gemma":0.0005114009,"domain_scores_codex":[0.9969435,0.0007372447,0.0006504277,0.0009798361,0.0003660133,0.0003229978],"domain_scores_gemma":[0.9976868,0.0009186245,0.0001057856,0.0009114784,0.0001275144,0.0002497691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005285897,0.01502349,0.06176925,0.00004885902,0.000443755,0.001608263,0.01870998,0.00001271834,0.8929018,0.000295564,0.0003619877,0.003538381],"study_design_scores_gemma":[0.0167258,0.07231893,0.8412698,0.00004972814,0.0007306209,0.0002575368,0.01040246,0.000199813,0.03571791,0.00005089489,0.02197714,0.0002993566],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884505,0.00129964,0.000005507738,0.006077685,0.0003142672,0.00353468,0.00004121541,0.0002451814,0.0000312763],"genre_scores_gemma":[0.998653,0.0001233097,0.0001396721,0.0004272489,0.00004260738,0.0005192648,0.00001455027,0.00005932778,0.0000210333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8571839,"threshold_uncertainty_score":0.9999912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274797807977747,"score_gpt":0.3212379657217738,"score_spread":0.2937581849239991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}