{"id":"W4399787377","doi":"10.1093/neuonc/noae064.442","title":"LGG-51. SYSTEMIC IMMUNE TOXICITY OF BRAF AND MEK-INHIBITORS IN CHILDREN: A PAN-CANADIAN SERIES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Princess Margaret Cancer Centre; Université Laval; Hospital for Sick Children","funders":"","keywords":"Medicine; Concomitant; Discontinuation; Adverse effect; MAPK/ERK pathway; Internal medicine; Pediatrics; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002495452,0.0006290666,0.0004103665,0.001585589,0.001497124,0.0006950593,0.0004891782,0.0006715709,0.003234999],"category_scores_gemma":[0.001174679,0.000327167,0.0005437459,0.00275231,0.0008448538,0.0003654325,0.000581773,0.0008653739,0.0004543798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006381928,"about_ca_system_score_gemma":0.006673858,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.4626964,"about_ca_topic_score_gemma":0.561918,"domain_scores_codex":[0.9993406,0.0000371411,0.00006026549,0.0001381964,0.000199686,0.0002240758],"domain_scores_gemma":[0.9988695,0.00008768524,0.0003367664,0.00004128533,0.0002793882,0.0003854517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001435412,0.00009002538,0.8926163,0.000278831,0.00009478915,0.07604151,0.001029341,0.0001692197,0.001510655,0.0005530212,0.005625629,0.02184704],"study_design_scores_gemma":[0.00004677559,0.0002272121,0.7629535,0.0003191506,0.0001358098,0.2184006,0.001881916,0.0002125667,0.0005217461,0.0001522574,0.01509837,0.00005006176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764539,0.007661116,0.0004174598,0.0009581306,0.00008953182,0.0001663131,0.002206683,0.00005194757,0.0119949],"genre_scores_gemma":[0.9932866,0.003742401,0.0003563001,0.000586392,0.00004792951,0.00002115008,0.0008554232,0.00002952463,0.001074278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5373036,"threshold_uncertainty_score":0.9200064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008781556336678464,"score_gpt":0.2556602766233873,"score_spread":0.2468787202867088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}