{"id":"W4399787415","doi":"10.1093/neuonc/noae064.455","title":"MDB-06. ALTERNATIVE SPLICING MEDIATED BY OTX2 DRIVES THE DEVELOPMENT OF GROUP 3 MEDULLOBLASTOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University; University of Manitoba; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Group (periodic table); RNA splicing; Alternative splicing; Computer science; Biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088307,0.0001953567,0.0001693429,0.0003077571,0.0001879572,0.0002778357,0.0001765551,0.0002601076,0.002707505],"category_scores_gemma":[0.00009799347,0.0001413851,0.0001929609,0.0001397107,0.0002500511,0.00008834655,0.0002713724,0.0006481413,0.0006318255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003891805,"about_ca_system_score_gemma":0.00024134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141473,"about_ca_topic_score_gemma":0.003272087,"domain_scores_codex":[0.9998442,0.00001679185,0.000010823,0.00003779917,0.00005557386,0.00003485699],"domain_scores_gemma":[0.9998418,0.0000220813,0.00004014971,0.00001335011,0.000008325369,0.0000742187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006823061,0.00002120142,0.0007245514,0.00001548355,0.000003124267,0.0001440758,0.00001595083,0.00002344904,0.9981667,0.0001056448,0.00006900066,0.0006426101],"study_design_scores_gemma":[0.00003781457,0.0002993435,0.03942864,0.00001233141,0.00002285794,0.001450841,0.0001162529,0.001775918,0.9485899,0.0001101327,0.008148756,0.000007293514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942987,0.0003768564,0.001696782,0.000117827,0.00002639805,0.00003788984,0.001138997,0.0001262694,0.002180262],"genre_scores_gemma":[0.9894276,0.000206979,0.001246811,0.00008516311,0.000007706663,0.00005251167,0.001354937,0.00008349162,0.007534841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002707505,"threshold_uncertainty_score":0.009057522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263286100909472,"score_gpt":0.2834669865758885,"score_spread":0.2708341255667938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}