{"id":"W4399787504","doi":"10.1093/neuonc/noae064.378","title":"IMMU-07. COMBINED PD1 AND LAG3 INHIBITION IN PRECLINICAL MODELS AND PATIENTS WITH DNA REPLICATION REPAIR DEFICIENT GLIOBLASTOMA (RRD-GBM): AN IRRDC STUDY","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Cancer research; Immune checkpoint; Immune system; CD8; Immunotherapy; Medicine; Nestin; Biology; Immunology; Stem cell; Neural stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000322824,0.0001894127,0.0003961143,0.0002073091,0.00006275785,0.00003005712,0.00003014074,0.0001343645,0.00001072927],"category_scores_gemma":[0.0001060051,0.0001453944,0.00003962899,0.0002483393,0.00009668813,0.0001535764,0.00007960306,0.0002268221,0.000008343462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001577465,"about_ca_system_score_gemma":0.0000899195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000407278,"about_ca_topic_score_gemma":0.0001924896,"domain_scores_codex":[0.9980769,0.0002282321,0.0004274554,0.0008289061,0.0002185153,0.0002200016],"domain_scores_gemma":[0.9988964,0.0003170388,0.00008602022,0.0004505155,0.0000897385,0.0001603526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006183342,0.02804788,0.899236,0.0002234488,0.0002358457,0.002431189,0.003865018,0.0001516563,0.01735121,0.001125516,0.001005214,0.04014365],"study_design_scores_gemma":[0.01881149,0.06326351,0.8990272,0.0002037609,0.000485081,0.0002280078,0.0004049043,0.01260743,0.003066498,0.0004493513,0.001173437,0.000279304],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963283,0.0002206078,0.000007718812,0.001121129,0.0001250622,0.001780518,0.00001202945,0.00015312,0.0002515277],"genre_scores_gemma":[0.9990408,0.00005879471,0.0001141679,0.0003471311,0.0000324613,0.0003223256,0.00004843559,0.00003085119,0.000005073686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03986434,"threshold_uncertainty_score":0.5929012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03071637505836091,"score_gpt":0.3307876099051599,"score_spread":0.300071234846799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}