{"id":"W4399787504","doi":"10.1093/neuonc/noae064.378","title":"IMMU-07. COMBINED PD1 AND LAG3 INHIBITION IN PRECLINICAL MODELS AND PATIENTS WITH DNA REPLICATION REPAIR DEFICIENT GLIOBLASTOMA (RRD-GBM): AN IRRDC STUDY","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Cancer research; Immune checkpoint; Immune system; CD8; Immunotherapy; Medicine; Nestin; Biology; Immunology; Stem cell; Neural stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001124994,0.001009876,0.00113222,0.0004694318,0.0002277052,0.0008369372,0.00070249,0.000589452,0.001449219],"category_scores_gemma":[0.0001872274,0.0003127479,0.0008359649,0.0004220806,0.0006484283,0.0004771199,0.0002978863,0.002395835,0.0006662637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006245998,"about_ca_system_score_gemma":0.001186059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000688174,"about_ca_topic_score_gemma":0.002057388,"domain_scores_codex":[0.999716,0.00008797071,0.00001616433,0.00005429516,0.00004356174,0.00008191674],"domain_scores_gemma":[0.9997618,0.00001696821,0.00004126574,0.00003982211,0.00001908978,0.0001211491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.09541887,0.0928603,0.01263698,0.001838191,0.00162967,0.0008132372,0.000491157,0.004672485,0.6183431,0.00117765,0.007592363,0.162526],"study_design_scores_gemma":[0.02592425,0.713167,0.02325044,0.0001395054,0.001606308,0.001621106,0.0003477095,0.003644745,0.210245,0.0004580266,0.01952601,0.00006987336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910432,0.004181774,0.0008871097,0.0003394651,0.000094565,0.0004389397,0.001030398,0.0001471499,0.001837311],"genre_scores_gemma":[0.9910493,0.002889425,0.001337778,0.0003346208,0.00006976546,0.0004613193,0.001936707,0.00003581733,0.001885302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449219,"threshold_uncertainty_score":0.005949616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03071637505836091,"score_gpt":0.3307876099051599,"score_spread":0.300071234846799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}