{"id":"W4399787624","doi":"10.1093/neuonc/noae064.198","title":"ETMR-28. EVALUATING THERAPEUTIC APPROACHES IN EMBRYONAL TUMORS WITH PLAGL1 AND PLAGL2 AMPLIFICATION AND UNRAVELING MOLECULAR PARALLELS IN EPIGENETICALLY RELATED TUMORS WITH PLAG1-ALTERATIONS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Parallels; Biology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005604909,0.0001771043,0.000317487,0.0002585664,0.0001066481,0.0002262328,0.0002441918,0.0002708681,0.001453648],"category_scores_gemma":[0.0003133955,0.00007518093,0.0002902981,0.0001666834,0.0001934399,0.0002788646,0.0001903665,0.0002935147,0.0001960183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000380211,"about_ca_system_score_gemma":0.0003192712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472976,"about_ca_topic_score_gemma":0.0007154091,"domain_scores_codex":[0.9998411,0.0000611675,0.00001299427,0.00003362976,0.00002289548,0.00002818435],"domain_scores_gemma":[0.9998513,0.00004133608,0.0000323578,0.0000177151,0.00001507931,0.00004212102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01870705,0.001413761,0.1575123,0.0006560246,0.0003624671,0.002226688,0.0001998745,0.005063717,0.6352985,0.0006695836,0.0007504775,0.1771395],"study_design_scores_gemma":[0.001795447,0.05470167,0.4703891,0.0001206626,0.0007851358,0.01093396,0.0004454002,0.01074376,0.4331361,0.0009506837,0.01595839,0.00003976375],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953022,0.002236205,0.0007977245,0.00007713957,0.000009217174,0.0000704172,0.0002173568,0.00001727152,0.001272509],"genre_scores_gemma":[0.9964749,0.0006046694,0.001716618,0.00005314268,0.00000887597,0.00007003771,0.000423649,0.000006214037,0.0006418058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453648,"threshold_uncertainty_score":0.004862905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808041833156861,"score_gpt":0.3301800400706763,"score_spread":0.2820996217391076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}