{"id":"W4399787812","doi":"10.1093/neuonc/noae064.085","title":"DIPG-32. NEOANTIGEN HEAT SHOCK PROTEIN VACCINE, RHSC-DIPGVAX, IS ASSOCIATED WITH INCREASED VACCINE-INDUCED B CELLS AND BCR/TCR REPERTOIRE DIVERSITY IN PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMAS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"breakpoint cluster region; Repertoire; T-cell receptor; Heat shock protein; Immunology; Medicine; Virology; Biology; Immune system; Receptor; Genetics; T cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679364,0.0001893004,0.0002900214,0.0002336884,0.0001327921,0.0002925567,0.0001220081,0.0002155542,0.001082807],"category_scores_gemma":[0.0003605488,0.0001125023,0.0001190327,0.0002332468,0.0001924971,0.0001786789,0.0001218239,0.0003506532,0.0001604067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003050498,"about_ca_system_score_gemma":0.0001966283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005445298,"about_ca_topic_score_gemma":0.0005653864,"domain_scores_codex":[0.999893,0.0000212575,0.000007258494,0.00003107654,0.00001933167,0.00002812876],"domain_scores_gemma":[0.9997221,0.00005612276,0.0001145341,0.00001304793,0.00002183817,0.00007237311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0129526,0.0007146035,0.6549037,0.0002756302,0.0001675145,0.008850145,0.0003739986,0.0009351437,0.2623506,0.0002900859,0.002358287,0.05582765],"study_design_scores_gemma":[0.0003222351,0.007698385,0.9331803,0.0000315261,0.0001321722,0.02361373,0.0003389231,0.001314611,0.02897221,0.0001740835,0.004207393,0.0000144203],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987974,0.0003366663,0.0001486177,0.00004480396,0.000003028217,0.00001026878,0.0002121167,0.00001740421,0.0004296874],"genre_scores_gemma":[0.9993489,0.000104342,0.0001142762,0.00002401582,0.000003970033,0.000006178705,0.0002538366,0.000003360165,0.0001410982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082807,"threshold_uncertainty_score":0.003622353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009175616349071639,"score_gpt":0.220773384264604,"score_spread":0.2115977679155323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}