{"id":"W4399787827","doi":"10.1093/neuonc/noae064.139","title":"DIPG-86. INVESTIGATING THE TUMOR ENVIRONMENT AND SIGNALING DEPENDENCIES DRIVING DIFFUSE MIDLINE GLIOMA TUMOR INITIATION, PROGRESSION, AND RESISTANCE: A COMPREHENSIVE APPROACH LEVERAGING BULK MULTIOMICS DECONVOLUTION AND SINGLE-CELL OMICS VALIDATION","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Deconvolution; Omics; Glioma; Cell; Computational biology; Cancer research; Medicine; Biology; Computer science; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000714544,0.0006352378,0.0007410552,0.0005660947,0.0003421168,0.000712355,0.0004206965,0.000651774,0.00145901],"category_scores_gemma":[0.0004396231,0.000328407,0.0006886031,0.000739078,0.0003053434,0.0002423463,0.0007065817,0.0008247049,0.0009550615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004045266,"about_ca_system_score_gemma":0.0006842542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975684,"about_ca_topic_score_gemma":0.003326994,"domain_scores_codex":[0.9996688,0.00003425387,0.00001719806,0.0001329167,0.00009529521,0.00005155963],"domain_scores_gemma":[0.9997894,0.00003522278,0.00003464074,0.00004411489,0.00005316782,0.00004345622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005546738,0.0001109295,0.02231887,0.0005103415,0.0001983216,0.0003478654,0.0001020921,0.005970188,0.9275279,0.0007221909,0.003098138,0.03853851],"study_design_scores_gemma":[0.0001698868,0.0012846,0.1774518,0.0001074658,0.0005939342,0.002910464,0.0003392677,0.05673607,0.7077776,0.002258362,0.05025573,0.0001147741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9048876,0.003672703,0.0451128,0.0005040282,0.00009628884,0.000298574,0.03830764,0.002252204,0.004868256],"genre_scores_gemma":[0.8846524,0.001612665,0.04898704,0.0006808885,0.00002359125,0.0003409297,0.05987573,0.0005051683,0.003321671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975684,"threshold_uncertainty_score":0.004880846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165552852474626,"score_gpt":0.2511516599822581,"score_spread":0.2294961314575119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}