{"id":"W4399787981","doi":"10.1093/neuonc/noae064.228","title":"EPEN-26. DRUG SCREENING IN PATIENT-DERIVED MODELS OF POSTERIOR FOSSA A EPENDYMOMA REVEALS NOVEL PHARMACOLOGICAL VULNERABILITIES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Ependymoma; Posterior fossa; Drug; Medicine; Computational biology; Computer science; Biology; Pharmacology; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535407,0.0004931907,0.00042887,0.0003335226,0.0001591929,0.000378155,0.0003645001,0.0004011379,0.001745343],"category_scores_gemma":[0.0001828416,0.0001351535,0.0003609999,0.0002368468,0.0002098543,0.0001672084,0.0001497765,0.0008779345,0.0005432477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003510768,"about_ca_system_score_gemma":0.0003063944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393182,"about_ca_topic_score_gemma":0.00236797,"domain_scores_codex":[0.9998494,0.00002673775,0.00001608311,0.00003302232,0.00004987072,0.00002483257],"domain_scores_gemma":[0.9998837,0.00002891321,0.00002101618,0.00001939514,0.0000174312,0.0000296822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005743495,0.0005884068,0.0007527237,0.0001121152,0.00003595821,0.0004591708,0.00002377001,0.001193869,0.9900093,0.0001771666,0.0005225274,0.005550526],"study_design_scores_gemma":[0.0002071194,0.005121467,0.008289522,0.0000183001,0.00007646949,0.001245313,0.00006317731,0.004905795,0.9702617,0.0001228164,0.009667337,0.00002096058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856973,0.002604521,0.003184585,0.0002962515,0.00008829145,0.0001973037,0.004785764,0.0001673612,0.002978761],"genre_scores_gemma":[0.9848862,0.001853287,0.002907964,0.0001112751,0.00001087855,0.0001310901,0.006037579,0.00002463657,0.004037039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001745343,"threshold_uncertainty_score":0.005838752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04859920495729063,"score_gpt":0.3290312899328204,"score_spread":0.2804320849755298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}