{"id":"W4399792922","doi":"10.1101/2024.06.15.598989","title":"Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diet and metabolism studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"mTORC1; Anabolism; Sarcopenia; Chemistry; Endocrinology; Internal medicine; Medicine; Pharmacology; Biochemistry; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492997,0.0002470969,0.0003583041,0.0003580676,0.0001716394,0.0004002639,0.0000647961,0.000186859,0.001959322],"category_scores_gemma":[0.0002172706,0.0002382146,0.0002002614,0.0002471308,0.0001786371,0.000129979,0.000176577,0.0002292889,0.0002771956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007041061,"about_ca_system_score_gemma":0.00005618968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007073261,"about_ca_topic_score_gemma":0.0008248975,"domain_scores_codex":[0.999939,0.000008572916,0.000004888536,0.00002535968,0.000008607273,0.00001359972],"domain_scores_gemma":[0.9998487,0.00001744897,0.00005752335,0.00001072725,0.0000132213,0.00005222517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008266831,0.0003009568,0.4378771,0.0001965684,0.0002861112,0.000639225,0.0004120907,0.0001228155,0.5384337,0.0000753282,0.0004230779,0.01296617],"study_design_scores_gemma":[0.00002169343,0.0003447125,0.9968699,0.000004582308,0.00004088126,0.0002382229,0.00007936815,0.0001044342,0.002072903,0.00002662146,0.0001940225,0.000002647251],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991084,0.0004710121,0.0001059835,0.00001379696,0.000006073062,0.000002464893,0.0001214653,0.000005132969,0.0001656958],"genre_scores_gemma":[0.9988862,0.0002004508,0.0001186688,0.00003749268,0.000015784,0.000006446854,0.0001918195,0.000002944191,0.00054027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001959322,"threshold_uncertainty_score":0.006554604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479343435059955,"score_gpt":0.244540853801252,"score_spread":0.2297474194506525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}