{"id":"W4399793241","doi":"10.1016/s2468-1253(24)00096-7","title":"Switching to tenofovir alafenamide in patients with virologically suppressed chronic hepatitis B and renal or hepatic impairment: final week 96 results from an open-label, multicentre, phase 2 study","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Université de Montréal","funders":"Gilead Sciences","keywords":"Tenofovir alafenamide; Tenofovir; Medicine; Chronic hepatitis; Hepatitis B; Hepatitis B virus; Internal medicine; Open label; Gastroenterology; Virology; Human immunodeficiency virus (HIV); Viral load; Adverse effect; Virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001504158,0.00131596,0.001865434,0.000268402,0.0002729852,0.000966275,0.0007381805,0.001148512,0.003399954],"category_scores_gemma":[0.001748366,0.0004325142,0.001468863,0.0003236916,0.0006418711,0.00107776,0.0002308489,0.002408918,0.0005452597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006553043,"about_ca_system_score_gemma":0.0005531057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009447212,"about_ca_topic_score_gemma":0.001842589,"domain_scores_codex":[0.9993355,0.0003588229,0.00003537989,0.00009038821,0.00005495105,0.0001250047],"domain_scores_gemma":[0.9989605,0.0003780806,0.0002195242,0.00008870002,0.00005998596,0.0002932629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9206792,0.009006084,0.003492323,0.0005984351,0.001354214,0.000104394,0.0001472381,0.0005393251,0.006785817,0.00006099168,0.0008665817,0.05636537],"study_design_scores_gemma":[0.8509769,0.1256033,0.01994534,0.00006359193,0.0007220056,0.0001309223,0.00008306014,0.0004668712,0.0009367077,0.0001459504,0.0008889964,0.00003625156],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960873,0.002066066,0.0001349759,0.0002044532,0.00009121781,0.0002409418,0.0003082512,0.00003025248,0.0008365602],"genre_scores_gemma":[0.9965041,0.0009466069,0.0003704513,0.0003586909,0.0001052668,0.0002775587,0.0004709834,0.000009164351,0.0009572711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003399954,"threshold_uncertainty_score":0.01137406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03817955350022249,"score_gpt":0.3237640657585484,"score_spread":0.2855845122583259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}