{"id":"W4399795849","doi":"10.1016/j.annonc.2024.06.010","title":"Development and validation of AI-assisted transcriptomic signatures to personalize adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; Queen's University","funders":"Unicancer; Canceropôle Provence-Alpes-Côte d’Azur; National Cancer Institute; Institut National Du Cancer; Canceropôle PACA; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Fondation Aix-Marseille Universite","keywords":"Gemcitabine; FOLFIRINOX; Medicine; Pancreatic ductal adenocarcinoma; Oncology; Regimen; Chemotherapy; Internal medicine; Pancreatic cancer; Adenocarcinoma; Chemotherapy regimen; Adjuvant; Adjuvant chemotherapy; Cancer; Oxaliplatin; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006726143,0.000317932,0.000438055,0.0007903377,0.0001274773,0.0005044862,0.000217623,0.0002924449,0.000408422],"category_scores_gemma":[0.001189771,0.00009451397,0.0003478223,0.0006748289,0.0001560484,0.0001437417,0.000252906,0.0003487741,0.0001555771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333738,"about_ca_system_score_gemma":0.0003335999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005861514,"about_ca_topic_score_gemma":0.0009229903,"domain_scores_codex":[0.9997039,0.00009170316,0.00002220791,0.00008520442,0.00006275623,0.00003409882],"domain_scores_gemma":[0.9994622,0.0002124381,0.0001537519,0.00004188768,0.00008793403,0.00004182062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004235942,0.0009333401,0.6113569,0.0003382141,0.000475843,0.0003510547,0.0001850906,0.03553294,0.1600157,0.0003017999,0.00204893,0.1842243],"study_design_scores_gemma":[0.000237738,0.003157266,0.6107184,0.00007240268,0.0005696859,0.0009616119,0.0003299204,0.3062148,0.07137837,0.001093067,0.005198422,0.00006836218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894461,0.0005306696,0.007125821,0.0000995361,0.00001256,0.00007382604,0.002211152,0.0000862157,0.000414131],"genre_scores_gemma":[0.9830744,0.0001930888,0.01055059,0.00005532224,0.00001765482,0.0001018545,0.005771058,0.00001160604,0.0002243829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007903377,"threshold_uncertainty_score":0.003557146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05035278832864643,"score_gpt":0.366300079028115,"score_spread":0.3159472906994685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}