{"id":"W4399799623","doi":"10.1038/s41564-024-01720-y","title":"Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature","year":2024,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Caspofungin; Biology; Mutagenesis; Virulence; Microbiology; Pathogen; Mutant; Antifungal drug; Drug resistance; Fluconazole; Gene; Genetics; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147822,0.0003020629,0.0001688157,0.0001736345,0.0001743088,0.0002480758,0.0001980671,0.0002400242,0.001365389],"category_scores_gemma":[0.0001893105,0.0001543326,0.0003022245,0.00009451235,0.0002568751,0.0001646508,0.0003385851,0.00043236,0.0002239086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584068,"about_ca_system_score_gemma":0.0001175097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003750333,"about_ca_topic_score_gemma":0.0004329811,"domain_scores_codex":[0.9998115,0.00006209994,0.00001563268,0.00003756321,0.00003545428,0.00003784714],"domain_scores_gemma":[0.9998857,0.00002455115,0.00004144894,0.00002387094,0.000007245992,0.00001714931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000187387,0.00001786771,0.0002702049,0.000009606467,0.000005151699,0.0000449462,0.00001234797,0.00007187727,0.9985046,0.0002129237,0.00002108192,0.0006420624],"study_design_scores_gemma":[0.00001437845,0.000496951,0.008153195,0.000008033905,0.00001641864,0.0005526922,0.0000477237,0.001501041,0.9877414,0.0001308693,0.001326416,0.00001101558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962875,0.0004721655,0.002085959,0.00007124327,0.00002544292,0.00001798435,0.0001485712,0.00005779931,0.0008333419],"genre_scores_gemma":[0.9985399,0.0001692934,0.0007664774,0.0000210173,0.000003474652,0.00001053508,0.0000626148,0.00001766689,0.0004090159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365389,"threshold_uncertainty_score":0.004567683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005360128409902279,"score_gpt":0.2556320170327876,"score_spread":0.2502718886228853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}