{"id":"W4399806161","doi":"10.1158/2767-9764.crc-23-0464","title":"KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis","year":2024,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Cancer Institute","keywords":"KRAS; GLI2; Cancer research; Transcription (linguistics); Carcinogenesis; Transcription factor; Pancreatic cancer; Chemistry; Biology; Internal medicine; Medicine; Genetics; Mutation; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001528122,0.0001497335,0.000360672,0.0005157629,0.0006845131,0.0001132877,0.000645177,0.0001360485,0.001042896],"category_scores_gemma":[0.000254435,0.0001288946,0.0001220955,0.0009794886,0.0006603353,0.0001587814,0.0002105306,0.00106585,0.0003931763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008167171,"about_ca_system_score_gemma":0.001572027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356017,"about_ca_topic_score_gemma":0.0006510693,"domain_scores_codex":[0.9971968,0.000610869,0.0003423783,0.0003857762,0.0008431091,0.0006210991],"domain_scores_gemma":[0.9967873,0.0006504408,0.00002276355,0.001721578,0.0005130479,0.0003048532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006435891,0.001172912,0.1260236,0.004088077,0.001657933,0.0003236061,0.009434895,0.000008323581,0.7961656,0.02235873,0.005424645,0.03269801],"study_design_scores_gemma":[0.007362277,0.002183552,0.7024101,0.009270941,0.002694601,0.0009541874,0.006274263,0.02640109,0.09554953,0.01458324,0.130865,0.001451277],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9007891,0.05908525,0.0001486843,0.02226568,0.00009267779,0.001415009,0.0000558231,0.0002251534,0.01592264],"genre_scores_gemma":[0.9573128,0.03011293,0.0007328811,0.00004144423,0.0001808527,0.001792557,0.00005211821,0.00004669673,0.009727675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7006161,"threshold_uncertainty_score":0.9998703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1919449759206567,"score_gpt":0.4782653957776401,"score_spread":0.2863204198569834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}