{"id":"W4399806930","doi":"10.1038/s41523-024-00653-3","title":"Use of ctDNA in early breast cancer: analytical validity and clinical potential","year":2024,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Svenska Sällskapet för Medicinsk Forskning","keywords":"Breast cancer; Circulating tumor DNA; Medicine; Oncology; Internal medicine; Clinical trial; Cancer; Minimal residual disease; Clinical Practice; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684001,0.0001567805,0.0002456779,0.00005844492,0.0000244267,0.00006657898,0.0001079052,0.0001932441,0.0001084348],"category_scores_gemma":[0.00002632877,0.000148744,0.0001337546,0.0001234229,0.0001819692,0.00001058753,0.0001375425,0.0001714235,0.000002983728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005404867,"about_ca_system_score_gemma":0.0003459075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004561188,"about_ca_topic_score_gemma":0.001403086,"domain_scores_codex":[0.9987662,0.00004864091,0.0003507415,0.0004543273,0.0001327809,0.0002473207],"domain_scores_gemma":[0.9994349,0.00004567356,0.00005435096,0.0002323561,0.00009354126,0.0001391856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007130404,0.0001957987,0.8986167,0.0001201513,0.000238362,0.00005321508,0.00004145279,0.000412798,0.0116936,0.0002566436,0.006542327,0.08111592],"study_design_scores_gemma":[0.0005873892,0.0001064991,0.9853953,0.0001233828,0.0001342277,0.00008906113,0.000008495196,0.002790393,0.001010709,0.00005974043,0.009451201,0.0002435842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942219,0.001814281,0.0001198959,0.00111439,0.0006624631,0.0001182779,0.001880917,0.000009275371,0.00005861922],"genre_scores_gemma":[0.9922293,0.006377064,0.00006547615,0.0002184732,0.0009035588,0.00001966706,0.00002846238,0.00002686883,0.0001311508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08677862,"threshold_uncertainty_score":0.6895182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02761222248979277,"score_gpt":0.3205653539150176,"score_spread":0.2929531314252248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}