{"id":"W4399808532","doi":"10.1016/j.xpro.2024.103143","title":"Protocol for the hyperinsulinemic euglycemic clamp to measure glucose kinetics in rats","year":2024,"lang":"en","type":"article","venue":"STAR Protocols","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Department of Psychiatry, University of Toronto; University of Toronto; Physicians' Services Incorporated Foundation; Centre for Addiction and Mental Health; Banting and Best Diabetes Centre, University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Clamp; Medicine; Glucose clamp technique; Hyperinsulinemia; Jugular vein; Carotid arteries; Artery; Internal medicine; Insulin; Cardiology; Pancreatic hormone; Insulin resistance; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002338401,0.002872322,0.002040608,0.00273159,0.002327631,0.001130896,0.002327253,0.002038284,0.03471074],"category_scores_gemma":[0.002045963,0.001302305,0.001698114,0.001744379,0.001354263,0.00123204,0.001392147,0.00593459,0.0138335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001561494,"about_ca_system_score_gemma":0.003582605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663569,"about_ca_topic_score_gemma":0.007095417,"domain_scores_codex":[0.9969254,0.000518332,0.0003689178,0.0007159594,0.001086324,0.0003851097],"domain_scores_gemma":[0.9971579,0.0002440046,0.0004067672,0.0008391118,0.0008721888,0.0004800817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009280996,0.007057456,0.002105749,0.001903089,0.0002810319,0.001059935,0.0008647706,0.002206353,0.8076535,0.01250694,0.05612087,0.09895933],"study_design_scores_gemma":[0.002611383,0.01273252,0.0167464,0.001240093,0.0005795062,0.001534136,0.0002696177,0.003908557,0.390887,0.006093249,0.5626968,0.0007009091],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"protocol","genre_scores_codex":[0.1056098,0.009247936,0.6815452,0.002306534,0.005179456,0.08926672,0.03773969,0.01449394,0.05461076],"genre_scores_gemma":[0.0660565,0.00975625,0.5973659,0.004504851,0.0005951291,0.2298206,0.02809334,0.001985473,0.06182186],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.03471074,"threshold_uncertainty_score":0.116119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07792668731971217,"score_gpt":0.3964780009571075,"score_spread":0.3185513136373953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}