{"id":"W4399833897","doi":"10.1016/j.immuni.2024.05.024","title":"Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria","year":2024,"lang":"en","type":"letter","venue":"Immunity","topic":"Malaria Research and Control","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"NHLBI Division of Intramural Research; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Deutsche Forschungsgemeinschaft; United States Agency for International Development","keywords":"Malaria; Plasmodium falciparum; Immunology; Biology; Autoantibody; Asymptomatic; Antibody; Seroprevalence; Antigen; Disease; Autoimmunity; Virology; Serology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0007177371,0.0004180422,0.00100092,0.0002221466,0.0002006102,0.000192349,0.0001901492,0.001359022,0.0001669606],"category_scores_gemma":[0.00163333,0.0003065722,0.0002031726,0.0002216576,0.000331008,0.00009796826,0.0002316408,0.007978515,0.00009236913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080092,"about_ca_system_score_gemma":0.000365442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002620463,"about_ca_topic_score_gemma":0.000284875,"domain_scores_codex":[0.9969504,0.0007513233,0.0005152763,0.0005726493,0.0006552276,0.0005550492],"domain_scores_gemma":[0.9982369,0.0005157928,0.0002628132,0.0005626639,0.0002633711,0.0001584432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003710396,0.0005805128,0.02589753,0.001902685,0.006835014,0.006237765,0.0003302477,2.464115e-7,0.0008999634,0.0001203405,0.9518065,0.001678793],"study_design_scores_gemma":[0.01117568,0.003692596,0.8296361,0.007396491,0.003070363,0.0001844155,0.0002382219,0.0008728756,0.0006328956,0.00237322,0.1393906,0.001336579],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1204728,0.0009959086,0.0000735662,0.8731332,0.0005485389,0.001839637,0.0006204633,0.0003631647,0.00195272],"genre_scores_gemma":[0.8828776,0.0002160472,0.00009493226,0.1045943,0.0029874,0.0002795089,0.002113789,0.0001542232,0.006682156],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8124159,"threshold_uncertainty_score":0.9999387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0442750769673915,"score_gpt":0.3063799835969726,"score_spread":0.2621049066295811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}