{"id":"W4399855182","doi":"10.1016/j.chembiol.2024.05.010","title":"Get your receptors in a knot with new Wnt signaling agonists","year":2024,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canada First Research Excellence Fund; University of Toronto; Deutsche Forschungsgemeinschaft","keywords":"Receptor; Wnt signaling pathway; Knot (papermaking); Biology; Cell biology; Signal transduction; Genetics; Engineering; Pulp and paper industry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332093,0.0002032128,0.0001858781,0.00005447234,0.00002344643,0.0000287439,0.0002402798,0.0003013657,0.0001735212],"category_scores_gemma":[0.00002360215,0.0001624181,0.00006628704,0.0001704699,0.0001108608,0.000002879099,0.0001037954,0.0002010977,0.00005523807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004250284,"about_ca_system_score_gemma":0.0002411363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003065751,"about_ca_topic_score_gemma":0.00000775992,"domain_scores_codex":[0.998737,0.00002663608,0.0002258534,0.0005820636,0.00006716567,0.0003612794],"domain_scores_gemma":[0.9996396,0.0000236817,0.00003469409,0.0001660981,0.00002775456,0.0001082204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067727,0.00002415224,0.002120959,0.00003182202,0.00003267496,0.000009123193,0.00008280941,0.0000159031,0.989464,0.00006018375,0.00575402,0.002297508],"study_design_scores_gemma":[0.0003748696,0.0001194091,0.00002005211,0.00004378734,0.00001113377,0.00001103229,0.00002564902,0.00001261928,0.9030339,0.0003242341,0.09577398,0.0002493846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909292,0.005280992,0.0007584101,0.0003166097,0.000355398,0.0001180275,0.000004619233,0.00004265369,0.002194122],"genre_scores_gemma":[0.995133,0.0001829457,0.001795859,0.0002499773,0.0004852864,0.00002705918,0.0002208578,0.00003202607,0.001872986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09001996,"threshold_uncertainty_score":0.6623219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247767660022825,"score_gpt":0.2480574447390456,"score_spread":0.2355797681388174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}