{"id":"W4399855182","doi":"10.1016/j.chembiol.2024.05.010","title":"Get your receptors in a knot with new Wnt signaling agonists","year":2024,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canada First Research Excellence Fund; University of Toronto; Deutsche Forschungsgemeinschaft","keywords":"Receptor; Wnt signaling pathway; Knot (papermaking); Biology; Cell biology; Signal transduction; Genetics; Engineering; Pulp and paper industry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000553878,0.00074826,0.000805157,0.0005815255,0.0006692462,0.001250758,0.0006157251,0.001063592,0.01663237],"category_scores_gemma":[0.0008542401,0.0006777234,0.0009192904,0.0003036808,0.0006252576,0.002453106,0.001455678,0.002676705,0.007760356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000415945,"about_ca_system_score_gemma":0.0002652052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000323562,"about_ca_topic_score_gemma":0.000743497,"domain_scores_codex":[0.9994777,0.000055884,0.00002161843,0.00007212118,0.0002296271,0.0001431371],"domain_scores_gemma":[0.9996617,0.00005102344,0.00005247438,0.00005428331,0.00004438908,0.0001362825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131234,0.0002119585,0.0007811351,0.0006620145,0.0001808373,0.0009760222,0.0002720944,0.0007362756,0.8982245,0.01017373,0.02304697,0.06360322],"study_design_scores_gemma":[0.0003439267,0.002322022,0.001527943,0.0001639524,0.0003230088,0.001893964,0.0004849385,0.002217122,0.6836576,0.006652271,0.3002299,0.0001832926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5329144,0.1001419,0.1479398,0.0433154,0.02059928,0.000913176,0.001938801,0.01042465,0.1418125],"genre_scores_gemma":[0.6792499,0.03475759,0.0536773,0.0148506,0.002158957,0.0004944959,0.0008846064,0.001230334,0.2126963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01663237,"threshold_uncertainty_score":0.05564088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247767660022825,"score_gpt":0.2480574447390456,"score_spread":0.2355797681388174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}