{"id":"W4399861185","doi":"10.1038/s41467-024-48926-6","title":"Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Genentech; U.S. National Library of Medicine; IXICO; H. Lundbeck A/S; National Cancer Institute; Servier; Eisai; Thompson Family Foundation; Northern California Institute for Research and Education; University of Southern California; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Mega-projects of Science Research for the 10th Five-Year Plan; Pfizer; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Astrocyte; Alzheimer's disease; Blood–brain barrier; Disease; Transcriptome; Neuroscience; Pericyte; Biology; Downregulation and upregulation; Medicine; Bioinformatics; Pathology; Central nervous system; Endothelial stem cell; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026012,0.0002717947,0.0003113428,0.0004728287,0.0002155547,0.0003250678,0.0001047362,0.0002144636,0.0006254208],"category_scores_gemma":[0.0002404839,0.000142371,0.0003491564,0.0003423913,0.000269133,0.0001963421,0.0002347646,0.0003148291,0.0001814915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603783,"about_ca_system_score_gemma":0.0002326653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001660823,"about_ca_topic_score_gemma":0.004426442,"domain_scores_codex":[0.9998677,0.00001123968,0.00001154095,0.00005106662,0.00003190606,0.00002648349],"domain_scores_gemma":[0.9998873,0.0000208088,0.00004296542,0.00001301314,0.00002185257,0.00001407515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003170378,0.00001701044,0.01364688,0.0001168655,0.00006384261,0.00008364969,0.0001154045,0.0003658344,0.9810421,0.0001431219,0.0001364942,0.003951693],"study_design_scores_gemma":[0.00002681507,0.0002894029,0.5922461,0.00005843014,0.0002555384,0.0007282117,0.0005161022,0.005352701,0.394776,0.001438886,0.004277763,0.00003415023],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913498,0.0009776299,0.003731233,0.00005957189,0.00001287977,0.00001315756,0.003280423,0.00007991619,0.0004954116],"genre_scores_gemma":[0.9906944,0.0008074163,0.004245475,0.0000980438,0.000008060414,0.00004068633,0.003349881,0.00003299784,0.0007230472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660823,"threshold_uncertainty_score":0.003302336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465691430099352,"score_gpt":0.2600379741063103,"score_spread":0.2453810598053168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}