{"id":"W4399861185","doi":"10.1038/s41467-024-48926-6","title":"Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Genentech; U.S. National Library of Medicine; IXICO; H. Lundbeck A/S; National Cancer Institute; Servier; Eisai; Thompson Family Foundation; Northern California Institute for Research and Education; University of Southern California; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Mega-projects of Science Research for the 10th Five-Year Plan; Pfizer; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Astrocyte; Alzheimer's disease; Blood–brain barrier; Disease; Transcriptome; Neuroscience; Pericyte; Biology; Downregulation and upregulation; Medicine; Bioinformatics; Pathology; Central nervous system; Endothelial stem cell; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002430033,0.0001490329,0.0001321087,0.0001425536,0.00009539565,0.00002937835,0.0004724486,0.0002905726,0.00002364265],"category_scores_gemma":[0.0001153337,0.000153909,0.0002321699,0.0003022248,0.0001074088,0.00001262218,0.00006738323,0.0004553992,0.000003377152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001358332,"about_ca_system_score_gemma":0.0001709683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002306976,"about_ca_topic_score_gemma":0.0001398602,"domain_scores_codex":[0.9989429,0.0001571681,0.0002767026,0.0002895397,0.0001836894,0.0001500502],"domain_scores_gemma":[0.9987465,0.00004836342,0.00003449983,0.0009683613,0.0001139354,0.00008838966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003828437,0.0002867813,0.0002256927,0.00002807958,0.000254461,0.000005172589,0.00008440863,0.0001506127,0.9468859,0.050707,0.000707161,0.0006264694],"study_design_scores_gemma":[0.004926396,0.0007661505,0.03204904,0.0007311442,0.003360621,0.00008290443,0.000360527,0.01433197,0.5995427,0.03210142,0.3096231,0.002123958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4326675,0.4779223,0.06380209,0.01892319,0.001496349,0.001508489,0.001165738,0.0001823742,0.002331907],"genre_scores_gemma":[0.9940615,0.0005842013,0.003437869,0.0005367313,0.00005280717,0.0000688197,0.001093263,0.00003062993,0.0001341345],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.561394,"threshold_uncertainty_score":0.6276228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465691430099352,"score_gpt":0.2600379741063103,"score_spread":0.2453810598053168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}