{"id":"W4399865664","doi":"10.1016/j.jbc.2024.107488","title":"RNA modifying enzymes shape tRNA biogenesis and function","year":2024,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transfer RNA; Biogenesis; RNA; Enzyme; Function (biology); Biochemistry; Biology; Chemistry; Computational biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693556,0.0003240783,0.0007404561,0.00004847216,0.00005824781,0.00006160902,0.0002608289,0.0006915757,0.00008083508],"category_scores_gemma":[0.00008524807,0.0001988151,0.0005799392,0.0001276541,0.0001091118,0.000003833668,0.0001240994,0.0003611287,0.00000731283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000038597,"about_ca_system_score_gemma":0.0001783423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.974343e-7,"about_ca_topic_score_gemma":9.063552e-8,"domain_scores_codex":[0.9986269,0.00005287237,0.0006412886,0.0003676119,0.0001234805,0.0001877976],"domain_scores_gemma":[0.9990372,0.00002390218,0.000484946,0.0002218324,0.0000989595,0.0001331465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004228865,0.00005003987,0.000008177193,0.003295137,0.0004808567,0.0000193251,0.000003041787,6.730612e-7,0.05858959,0.00001557922,0.0028848,0.9346105],"study_design_scores_gemma":[0.0001204003,0.0001646467,0.000006097076,0.001221145,0.0006797339,0.0004001715,0.00001858443,0.000003679362,0.006498575,0.00006368501,0.9905581,0.0002651702],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005546322,0.993656,0.00009073844,0.00003574801,0.000204924,0.00008284167,0.00005647479,0.00000809682,0.0003188542],"genre_scores_gemma":[0.005383589,0.9925963,0.0001209884,0.00003380116,0.001270368,0.00001671823,0.00009245169,0.00002758705,0.000458205],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9876733,"threshold_uncertainty_score":0.8107446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0677183203311774,"score_gpt":0.3228098783718258,"score_spread":0.2550915580406484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}