{"id":"W4399881054","doi":"10.1200/jco.2024.42.16_suppl.4109","title":"Association between beta-catenin (<i>CTNNB1</i>) mutations and clinical outcomes of pembrolizumab in advanced hepatocellular carcinoma (aHCC): Exploratory analyses from KEYNOTE-240.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Internal medicine; Oncology; Pembrolizumab; Hepatocellular carcinoma; Hazard ratio; Logistic regression; Concordance; Wnt signaling pathway; Population; Proportional hazards model; Placebo; Cancer; Confidence interval; Immunotherapy; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002444975,0.000476371,0.0004749974,0.0003478939,0.0002411507,0.0004375736,0.0004217222,0.0003696316,0.002052761],"category_scores_gemma":[0.001798201,0.0002293457,0.001038721,0.0003245246,0.0002833072,0.0004110321,0.0005389358,0.0007497161,0.0001921183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004271615,"about_ca_system_score_gemma":0.0004080723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003959321,"about_ca_topic_score_gemma":0.0009995183,"domain_scores_codex":[0.9991321,0.0003982522,0.00005721702,0.0001944983,0.0001207615,0.00009718316],"domain_scores_gemma":[0.9979367,0.0007820607,0.000669851,0.0002197996,0.00009250217,0.0002990458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1627127,0.001770513,0.7969356,0.0003567052,0.005309192,0.0002069111,0.0001933,0.00102315,0.01308807,0.0001250488,0.001042743,0.01723608],"study_design_scores_gemma":[0.005436286,0.02148728,0.9653612,0.0000323945,0.002377204,0.0004150373,0.0001228526,0.001458833,0.002201853,0.0001765085,0.0009103276,0.00002023302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986149,0.0003113509,0.0001122086,0.00002856959,0.000003591615,0.00005629977,0.000652638,0.000005377464,0.0002150224],"genre_scores_gemma":[0.9988703,0.0000417073,0.000165962,0.00003207963,0.000009150439,0.00005865316,0.0007023544,0.000002828916,0.0001169186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444975,"threshold_uncertainty_score":0.01293039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1065850512020403,"score_gpt":0.4427904849517239,"score_spread":0.3362054337496836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}