{"id":"W4399881164","doi":"10.1200/jco.2024.42.16_suppl.4129","title":"Safety, efficacy, and PKPD of 23ME-00610, a first-in-class anti-CD200R1 antibody, in patients with advanced neuroendocrine cancers: Results from a multi-center multi-country phase 1/2a expansion cohort.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Cohort; Antibody; Oncology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561876,0.0004181156,0.0005532283,0.000199341,0.0002855329,0.0005983359,0.0003116442,0.0003835144,0.001491539],"category_scores_gemma":[0.000633381,0.0002073067,0.0006278405,0.0002757935,0.0003053728,0.0004905126,0.0003247252,0.0009956686,0.0006007058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004877313,"about_ca_system_score_gemma":0.0005371581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005060852,"about_ca_topic_score_gemma":0.001163199,"domain_scores_codex":[0.9996483,0.0001362001,0.00002608668,0.00007735504,0.00006391015,0.00004817672],"domain_scores_gemma":[0.9993417,0.0001110358,0.0001539149,0.00008714766,0.00006129066,0.0002450014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2294825,0.01962723,0.4801663,0.0004610481,0.002624816,0.001150687,0.000733844,0.003896824,0.08876444,0.000202951,0.00752278,0.1653666],"study_design_scores_gemma":[0.05218707,0.2189388,0.6954672,0.00006868358,0.001544109,0.004078261,0.0003367127,0.003562751,0.01270374,0.0002649477,0.01076896,0.0000788414],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979023,0.0004114804,0.0001618882,0.00006103317,0.000006578231,0.0001495335,0.0007506504,0.00001442005,0.0005422359],"genre_scores_gemma":[0.9949881,0.0003097976,0.000423372,0.0002295363,0.00002403585,0.0001703251,0.003181324,0.00001049338,0.0006629635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561876,"threshold_uncertainty_score":0.008260131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04618754680713361,"score_gpt":0.4433493690343295,"score_spread":0.3971618222271959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}