{"id":"W4399881578","doi":"10.1016/j.cllc.2024.06.007","title":"MDT-BRIDGE: Neoadjuvant Durvalumab Plus Chemotherapy Followed by Either Surgery and Adjuvant Durvalumab or Chemoradiotherapy and Consolidation Durvalumab in Resectable or Borderline-resectable Stage IIB–IIIB NSCLC","year":2024,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"AstraZeneca","keywords":"Durvalumab; Medicine; Chemoimmunotherapy; Chemoradiotherapy; Chemotherapy; Oncology; Neoadjuvant therapy; Gemcitabine; Internal medicine; Stage (stratigraphy); Surgery; Cancer; Immunotherapy; Breast cancer; Nivolumab; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001805033,0.0007063469,0.002095467,0.0002835072,0.0001901109,0.0002760792,0.0001793998,0.0004915572,0.00262792],"category_scores_gemma":[0.0005041817,0.0004962808,0.0003274468,0.0008222043,0.000404893,0.0003998249,0.00009740835,0.0007724111,0.00001661998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001328908,"about_ca_system_score_gemma":0.002440956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00325942,"about_ca_topic_score_gemma":0.003015305,"domain_scores_codex":[0.9947829,0.0003386937,0.001591237,0.001645167,0.000670272,0.0009716913],"domain_scores_gemma":[0.9960431,0.00215542,0.0002945733,0.0007748974,0.0001856702,0.0005462668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03892535,0.002203547,0.379178,0.003488724,0.002932774,0.001765423,0.00168807,0.0000604917,0.001204834,0.00009037586,0.3486034,0.219859],"study_design_scores_gemma":[0.127671,0.007944006,0.2879624,0.01680421,0.002857811,0.0005076697,0.0007406707,0.06653862,0.007571186,0.0001184622,0.4772142,0.004069733],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8983244,0.08615769,0.0001077025,0.009986379,0.001504412,0.002795941,0.0003348609,0.0002698795,0.0005187333],"genre_scores_gemma":[0.8595356,0.1117061,0.0003686521,0.003197647,0.0009761858,0.001144938,0.0001954384,0.0002815468,0.02259398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2157892,"threshold_uncertainty_score":0.9997489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04781090545811995,"score_gpt":0.4172892982631643,"score_spread":0.3694783928050444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}