{"id":"W4399881586","doi":"10.1371/journal.pgen.1011101","title":"Filamin protects myofibrils from contractile damage through changes in its mechanosensory region","year":2024,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Filamin; Mechanosensitive channels; Sarcomere; Actin; Cell biology; Biology; Myofibril; Cytoskeleton; Stress fiber; Anatomy; Mutant; Actin cytoskeleton; Biophysics; Myocyte; Genetics; Focal adhesion; Biochemistry; Ion channel; Signal transduction; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007635414,0.000294439,0.0001564571,0.000162223,0.0001893271,0.000269313,0.0003600265,0.0004136297,0.0009156294],"category_scores_gemma":[0.0001076258,0.0001535659,0.0002278219,0.00005810379,0.0002824943,0.0002102889,0.0002885126,0.0005177216,0.00019468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003081794,"about_ca_system_score_gemma":0.0001227498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000839892,"about_ca_topic_score_gemma":0.0008691409,"domain_scores_codex":[0.9999216,0.000006658038,0.000009506108,0.00002084789,0.00002154754,0.00001977792],"domain_scores_gemma":[0.9998413,0.00002318508,0.0000667072,0.00001962258,0.00001270232,0.00003629192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002531376,0.000005951549,0.0001208356,0.00000774628,0.000003155844,0.00001913039,0.000003196292,0.00001881669,0.99958,0.00002552169,0.000003788913,0.000186653],"study_design_scores_gemma":[0.000007323419,0.00007310172,0.008198787,0.000002995818,0.00001003783,0.0001304146,0.00001675633,0.0003392341,0.9906977,0.00002081103,0.0004993655,0.000003470739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975994,0.0003794215,0.001331312,0.00005779898,0.00001043908,0.000007290692,0.0001314229,0.00003772885,0.0004451866],"genre_scores_gemma":[0.9977025,0.0002146717,0.001008434,0.00003673213,0.000003813653,0.000007916442,0.0001532857,0.00001392448,0.0008586656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009156294,"threshold_uncertainty_score":0.003063023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119511403332203,"score_gpt":0.2604857214147744,"score_spread":0.2292906073814523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}