{"id":"W4399881586","doi":"10.1371/journal.pgen.1011101","title":"Filamin protects myofibrils from contractile damage through changes in its mechanosensory region","year":2024,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Filamin; Mechanosensitive channels; Sarcomere; Actin; Cell biology; Biology; Myofibril; Cytoskeleton; Stress fiber; Anatomy; Mutant; Actin cytoskeleton; Biophysics; Myocyte; Genetics; Focal adhesion; Biochemistry; Ion channel; Signal transduction; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005500923,0.0001910892,0.0001601011,0.00006544907,0.00004723485,0.00007249355,0.0001528133,0.0002233562,0.0001018018],"category_scores_gemma":[0.00006619686,0.0001964669,0.00007320493,0.0001248756,0.00001883821,0.0000079185,0.0001030821,0.0001888441,0.00006512025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002792331,"about_ca_system_score_gemma":0.00005801117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001935425,"about_ca_topic_score_gemma":0.0002489684,"domain_scores_codex":[0.9988531,0.00006528298,0.0001942365,0.0004753452,0.0001421951,0.0002698537],"domain_scores_gemma":[0.9994382,0.00002964034,0.00005052888,0.0003644908,0.00006057492,0.00005661128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002533587,0.00007142554,0.00001306721,0.00004091315,0.00006208759,0.00005922559,0.0001458887,0.00002219617,0.9970496,0.0002483124,0.001390636,0.0008712773],"study_design_scores_gemma":[0.0001818123,0.0001859792,0.00003301003,0.0001097391,0.00002727769,0.00001304205,0.0000912697,0.008229333,0.9051614,0.0005316515,0.08522393,0.000211604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873183,0.007507728,0.001472814,0.0006562466,0.0006318676,0.0005840505,0.0001151202,0.00005027679,0.001663643],"genre_scores_gemma":[0.9950055,0.001976726,0.0004386115,0.000250985,0.0005527392,0.00008179846,0.0002213676,0.00005493736,0.001417351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09188828,"threshold_uncertainty_score":0.8011689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119511403332203,"score_gpt":0.2604857214147744,"score_spread":0.2292906073814523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}