{"id":"W4399901966","doi":"10.1158/1535-7163.mct-23-0393","title":"Anti-Claudin-2 Antibody–Drug Conjugates for the Treatment of Colorectal Cancer Liver Metastasis","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University","funders":"Institute of Cancer Research","keywords":"Metastasis; Colorectal cancer; Claudin; Cancer; Cancer research; Monoclonal antibody; Antibody; In vivo; Antibody-drug conjugate; Medicine; Liver cancer; Immunology; Biology; Internal medicine; Tight junction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002333736,0.0002911841,0.0005128777,0.0001283509,0.0001099122,0.00006347671,0.0002073955,0.00009041766,0.0004590474],"category_scores_gemma":[0.000009645069,0.0001844438,0.0004098111,0.0004560076,0.0002970605,0.00004016858,0.00002997343,0.0001782393,0.00001250327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004855522,"about_ca_system_score_gemma":0.0007937137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001380787,"about_ca_topic_score_gemma":0.000221671,"domain_scores_codex":[0.9981714,0.00007811734,0.0003217245,0.0004321635,0.0005203002,0.0004762281],"domain_scores_gemma":[0.9988357,0.0003110841,0.00006889264,0.0003986964,0.0002787269,0.0001068411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007557618,0.0004855191,0.004267513,0.001176994,0.007511167,0.0002265136,0.003010606,0.0004209065,0.6871908,0.0008385787,0.001668234,0.2924474],"study_design_scores_gemma":[0.001149516,0.0007035175,0.0009741515,0.0002913543,0.001800386,0.00001608533,0.0001256288,0.009329237,0.6276931,0.00007864441,0.3576507,0.0001877548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5420891,0.4420489,0.002443314,0.009104317,0.0009393907,0.002371912,0.0006777824,0.0001017077,0.0002235114],"genre_scores_gemma":[0.8906509,0.1059026,0.0004686055,0.000879648,0.0002576707,0.0009227569,0.00003199258,0.000109984,0.0007758111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3559825,"threshold_uncertainty_score":0.7521402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06740540409596586,"score_gpt":0.4121118355728409,"score_spread":0.344706431476875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}