{"id":"W4399902350","doi":"10.1016/j.ccrj.2024.03.004","title":"Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults in the intensive care unit with suspected hypoxic ischaemic encephalopathy following a cardiac arrest (Mega-ROX HIE)","year":2024,"lang":"en","type":"article","venue":"Critical Care and Resuscitation","topic":"Cardiac Arrest and Resuscitation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health; University of Alberta; Alberta Health Services","funders":"","keywords":"Medicine; Intensive care unit; Randomized controlled trial; Mega-; Protocol (science); Ischaemic heart disease; Emergency medicine; Intensive care medicine; Medical emergency; Cardiology; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.113148,0.006935373,0.01178504,0.004498117,0.003103753,0.007004097,0.004240485,0.01045573,0.1996229],"category_scores_gemma":[0.240975,0.004574933,0.01064588,0.006687046,0.0045256,0.004933889,0.003250807,0.0143192,0.03599114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008019296,"about_ca_system_score_gemma":0.02101792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002859012,"about_ca_topic_score_gemma":0.005143555,"domain_scores_codex":[0.8799639,0.08484284,0.01505003,0.006723898,0.009506423,0.003912916],"domain_scores_gemma":[0.8947215,0.04927946,0.01711991,0.01760595,0.01692566,0.004347567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3776323,0.002240062,0.001406797,0.1197679,0.009042334,0.0007609146,0.001535091,0.006224908,0.002281577,0.03108571,0.3723148,0.07570761],"study_design_scores_gemma":[0.591398,0.01009772,0.004603359,0.05130528,0.004722735,0.0004177365,0.0004737764,0.0155396,0.002477958,0.04788057,0.2704589,0.0006243184],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0005185874,0.0002862892,0.005667045,0.001055111,0.00154046,0.9760131,0.01211407,0.0005474662,0.002257769],"genre_scores_gemma":[0.0007289317,0.00006899067,0.005198976,0.0003047108,0.00008323944,0.9923249,0.0005862141,0.0000407257,0.0006633115],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1996229,"threshold_uncertainty_score":0.6678051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513658558488647,"score_gpt":0.3305626930774003,"score_spread":0.3054261074925138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}