{"id":"W4399903801","doi":"10.1016/j.bcp.2024.116383","title":"The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding","year":2024,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Consiglio Nazionale delle Ricerche","keywords":"Orexin; Internal medicine; Energy homeostasis; Endocrinology; Hypothalamus; Leptin; Butyrate; Lateral hypothalamus; Chemistry; Orexin-A; Propionate; Neuron; Leptin receptor; Biology; Receptor; Neuropeptide; Biochemistry; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009488422,0.0002899153,0.0002860277,0.0001212872,0.00009745207,0.000218495,0.0001841847,0.0003022161,0.0006960738],"category_scores_gemma":[0.00005785516,0.0001231321,0.0002358836,0.00008488418,0.0002596757,0.0002623676,0.0002101314,0.000314933,0.000107409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136947,"about_ca_system_score_gemma":0.0001565598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004249875,"about_ca_topic_score_gemma":0.0008670015,"domain_scores_codex":[0.9999341,0.000008011239,0.000005895169,0.00001935172,0.00001356626,0.00001916721],"domain_scores_gemma":[0.9999571,0.000003768457,0.00001330919,0.000004067483,0.000006241963,0.00001549646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003078575,0.00001151282,0.0002924445,0.00003418261,0.000005016439,0.00006169399,0.000008662547,0.00001352385,0.9980907,0.00004058894,0.000008703354,0.001125136],"study_design_scores_gemma":[0.0001444667,0.001095065,0.1236562,0.00003602091,0.00008734655,0.0007262506,0.0001659967,0.001248968,0.8696274,0.0004508545,0.002740635,0.00002059546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933904,0.003021203,0.002495154,0.0001497322,0.00003673564,0.00002325556,0.0001487832,0.00003323251,0.0007013615],"genre_scores_gemma":[0.9927055,0.0024752,0.002234612,0.0001198952,0.00002641675,0.00004404716,0.0001328374,0.00001176404,0.002249686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006960738,"threshold_uncertainty_score":0.002328575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0409470515910985,"score_gpt":0.3192550876665077,"score_spread":0.2783080360754092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}