{"id":"W4399908080","doi":"10.1021/acs.jmedchem.4c00706","title":"Bifunctionality and Antitumor Efficacy of ZG-126, a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Calcitriol receptor; Chemistry; Histone deacetylase; Cancer research; Pharmacology; Agonist; Histone deacetylase inhibitor; In vivo; Melanoma; Nuclear receptor; Receptor; Biochemistry; Histone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070002,0.0001694678,0.0001219191,0.000192812,0.0000749102,0.0001557048,0.0001125691,0.0001809451,0.0006965635],"category_scores_gemma":[0.00006455286,0.00005821155,0.0001134821,0.0001370032,0.0001405061,0.0001114435,0.00009994165,0.0002486278,0.0001473926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244018,"about_ca_system_score_gemma":0.0001021897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004438954,"about_ca_topic_score_gemma":0.0005355199,"domain_scores_codex":[0.9999363,0.00001253707,0.000004266778,0.00001008347,0.00002138857,0.00001544739],"domain_scores_gemma":[0.9999679,0.000005339881,0.000009812734,0.000003342272,0.000003885965,0.000009715427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002025946,0.00004995752,0.000134682,0.0000205757,0.000005672064,0.00001296045,0.000006594113,0.0002401712,0.995814,0.0001106018,0.00004201156,0.003360127],"study_design_scores_gemma":[0.00003445635,0.001037369,0.001379985,0.000001857961,0.00001590113,0.000070824,0.000005425619,0.0005863613,0.9958788,0.00001722559,0.0009689426,0.000002951563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963796,0.000971868,0.0008894193,0.00003653612,0.000009023097,0.0000212951,0.0001694168,0.00002911853,0.001493909],"genre_scores_gemma":[0.9979342,0.0003749538,0.0007603171,0.00001461129,0.000002542107,0.000009114337,0.0001589726,0.000004395803,0.0007408555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006965635,"threshold_uncertainty_score":0.002330244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008835319042278704,"score_gpt":0.2932586248597802,"score_spread":0.2844233058175015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}