{"id":"W4399918549","doi":"10.1038/s41419-024-06822-3","title":"Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Division of Molecular and Cellular Biosciences; National Heart, Lung, and Blood Institute; Pelotonia; Ohio State University; National Cancer Institute; National Institutes of Health; National Science Foundation; U.S. Department of Health and Human Services; Yale University; National Institute of General Medical Sciences; American Heart Association","keywords":"Endocytosis; Apoptosis; Cell biology; Cancer cell; Chemistry; Cancer research; Cancer; Biology; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005540918,0.0001394528,0.0001142383,0.00007000157,0.00005306329,0.00003353852,0.00003512036,0.00007682199,0.0000394319],"category_scores_gemma":[0.00001057612,0.0001246002,0.00009499814,0.00008420114,0.00001311984,0.000004987917,0.00005744595,0.0000337442,0.000008289583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001129186,"about_ca_system_score_gemma":0.00008613577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004440156,"about_ca_topic_score_gemma":0.000004938698,"domain_scores_codex":[0.9992099,0.00002355099,0.0001411925,0.0003486673,0.0001077983,0.0001688747],"domain_scores_gemma":[0.9994132,0.00000811713,0.00002730547,0.0001716703,0.00004904267,0.0003306516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008475468,0.00003424516,0.00004039541,0.0001818746,0.00001759171,0.000006331712,0.00004016071,0.00006408609,0.9934059,0.0003256823,0.0008383026,0.004960709],"study_design_scores_gemma":[0.000220331,0.0001091153,0.0002328131,0.00006181856,0.00009462324,8.61719e-7,0.00003311582,0.000573456,0.9956943,0.0003359261,0.002480685,0.0001629832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937658,0.002486831,0.002533715,0.0001638368,0.0002963078,0.000231649,0.0001197997,0.00002202643,0.00038009],"genre_scores_gemma":[0.9975307,0.0009003961,0.0002847094,0.0002237258,0.0001828278,0.00003519591,0.0000967926,0.00002112861,0.0007245385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004797726,"threshold_uncertainty_score":0.508105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009992021954617658,"score_gpt":0.2414125729071675,"score_spread":0.2314205509525499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}