{"id":"W4399929256","doi":"10.1111/all.16178","title":"Real‐world biologics response and super‐response in the International Severe Asthma Registry cohort","year":2024,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; University of Alberta; Vancouver General Hospital; University of British Columbia","funders":"Optimum Patient Care; Sanofi; GlaxoSmithKline; Teva Pharmaceutical Industries; Seqirus; AstraZeneca","keywords":"Medicine; Asthma; Cohort; Cohort study; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007999131,0.0001184021,0.0001360357,0.0001592498,0.00004577815,0.0000513602,0.0001470814,0.00007367058,0.0002405291],"category_scores_gemma":[0.0003404023,0.00007234213,0.00006175088,0.0001995644,0.0001210118,0.00005438464,0.00006186237,0.000191098,0.00003085068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006059694,"about_ca_system_score_gemma":0.0002227763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000584976,"about_ca_topic_score_gemma":0.0001033917,"domain_scores_codex":[0.9989155,0.0002700584,0.0001784541,0.0002653304,0.0002163006,0.0001543417],"domain_scores_gemma":[0.9990283,0.0005932875,0.00002043048,0.0002495883,0.00003135137,0.00007702734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1094342,0.001011982,0.4991371,0.000273895,0.001135775,0.02390366,0.004340791,0.00009895325,0.0374514,0.01081187,0.2731228,0.03927756],"study_design_scores_gemma":[0.0003057036,0.0001830826,0.5450048,0.00008059556,0.000007862371,0.0001705987,0.0003589318,0.000137275,0.00004476498,0.00005981532,0.4535755,0.0000710699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838648,0.001299397,0.000004079405,0.009827917,0.000210367,0.0001539141,0.00002973476,0.00006231903,0.004547494],"genre_scores_gemma":[0.9912109,0.0004273685,0.00004448338,0.001800461,0.0001892054,0.00002794515,0.0000340825,0.00001409727,0.006251482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1804527,"threshold_uncertainty_score":0.2950027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465171668153047,"score_gpt":0.2866480230620818,"score_spread":0.2719963063805513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}