{"id":"W4399970144","doi":"10.1016/j.stem.2024.05.010","title":"Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging","year":2024,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Radcliffe Department of Medicine, University of Oxford; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Blood Cancer UK; Clarendon Fund; Medical Research Council; Versus Arthritis; National Research Council Canada; University of Toronto; Canadian Cancer Society Research Institute; Canada First Research Excellence Fund; Canada Research Chairs; International Development Research Centre; Terry Fox Foundation; University of Oxford; Canadian Cancer Society; National Institute for Health and Care Research; Government of Ontario; Princess Margaret Cancer Foundation; Pfizer; NIHR Oxford Biomedical Research Centre; Ontario Institute for Cancer Research; Ministry of Health, Ontario","keywords":"Biology; Haematopoiesis; Mutant; Stem cell; Transcriptome; Inflammation; Myeloid; Cell biology; Progenitor cell; Bone marrow; Mutation; Hematopoietic stem cell; Somatic cell; Genetics; Immunology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002922562,0.0001399824,0.0001924898,0.0004106829,0.0001395412,0.0003452665,0.0000953858,0.0001901771,0.001132704],"category_scores_gemma":[0.0003630506,0.0001181302,0.0001361869,0.0002679875,0.000185301,0.0001056584,0.0002327947,0.0002367095,0.0001881972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001117419,"about_ca_system_score_gemma":0.0001093961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003521909,"about_ca_topic_score_gemma":0.0008029481,"domain_scores_codex":[0.9997666,0.00002803346,0.00001842432,0.0000772209,0.00007281375,0.00003683327],"domain_scores_gemma":[0.9997604,0.00005583092,0.00009036648,0.00003869608,0.00002695961,0.0000277161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000163161,0.00001084084,0.01778379,0.00003159096,0.00002014245,0.00007325796,0.00005921052,0.0001096748,0.9772618,0.0001145336,0.00006556764,0.004306401],"study_design_scores_gemma":[0.00001418314,0.0002799837,0.4004786,0.00002050077,0.00009637651,0.001487306,0.0001463865,0.001521412,0.5915227,0.0004008992,0.00401785,0.00001378294],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943454,0.0007421161,0.003472183,0.00003393546,0.00000508544,0.00001762739,0.0008498161,0.00006671695,0.0004670509],"genre_scores_gemma":[0.9967175,0.0001968157,0.001982442,0.0000429647,0.000003600867,0.00002043662,0.0006232149,0.00001987535,0.0003932269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132704,"threshold_uncertainty_score":0.003789246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164797988539226,"score_gpt":0.2690622350208543,"score_spread":0.2574142551354621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}