{"id":"W4399970144","doi":"10.1016/j.stem.2024.05.010","title":"Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging","year":2024,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Radcliffe Department of Medicine, University of Oxford; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Blood Cancer UK; Clarendon Fund; Medical Research Council; Versus Arthritis; National Research Council Canada; University of Toronto; Canadian Cancer Society Research Institute; Canada First Research Excellence Fund; Canada Research Chairs; International Development Research Centre; Terry Fox Foundation; University of Oxford; Canadian Cancer Society; National Institute for Health and Care Research; Government of Ontario; Princess Margaret Cancer Foundation; Pfizer; NIHR Oxford Biomedical Research Centre; Ontario Institute for Cancer Research; Ministry of Health, Ontario","keywords":"Biology; Haematopoiesis; Mutant; Stem cell; Transcriptome; Inflammation; Myeloid; Cell biology; Progenitor cell; Bone marrow; Mutation; Hematopoietic stem cell; Somatic cell; Genetics; Immunology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009962887,0.0002339389,0.0004670856,0.0005512229,0.00006790728,0.00004521694,0.0001086068,0.0001440311,0.00004701478],"category_scores_gemma":[0.00001360767,0.0001998112,0.00005438325,0.001054156,0.0000720965,0.0001176847,0.00009809314,0.0004250312,0.00003637589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007959226,"about_ca_system_score_gemma":0.0003497945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006828929,"about_ca_topic_score_gemma":0.00003609418,"domain_scores_codex":[0.9978868,0.0002654774,0.0004564484,0.0004821036,0.000501446,0.0004077142],"domain_scores_gemma":[0.9987389,0.0005074351,0.000112664,0.0002552535,0.0002017253,0.0001840544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001132444,0.00007827352,0.002436166,0.0008438054,0.00007083653,0.0005750823,0.008055266,0.00003611142,0.9857681,0.000006866386,0.0004852104,0.0005117776],"study_design_scores_gemma":[0.002074712,0.0006303873,0.003041825,0.0009308176,0.00007557531,0.00002216207,0.003018897,0.001627761,0.9878927,0.000006747126,0.0004706028,0.0002078053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966754,0.0002988422,0.00007239442,0.0003998675,0.00003284973,0.0009185273,0.00005576532,0.00008042882,0.00146593],"genre_scores_gemma":[0.9930523,0.00002494939,0.00009167623,0.00005977149,0.00002784137,0.00003442542,0.00002051091,0.00006025324,0.006628293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005162362,"threshold_uncertainty_score":0.8148066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164797988539226,"score_gpt":0.2690622350208543,"score_spread":0.2574142551354621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}