{"id":"W4399973113","doi":"10.1093/neuonc/noae108","title":"No benefit from TMZ treatment in glioblastoma with truly unmethylated <i>MGMT</i> promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly glioblastoma patients","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Canadian Cancer Society Research Institute; Deutschen Konsortium für Translationale Krebsforschung; Universität Zürich; Centre Hospitalier Universitaire Vaudois; Umeå Universitet; Linköpings Universitet; Université de Lausanne; European Organisation for Research and Treatment of Cancer; Deutsches Krebsforschungszentrum","keywords":"Temozolomide; Methyltransferase; Oncology; Medicine; Internal medicine; Clinical trial; O-6-methylguanine-DNA methyltransferase; Population; Radiation therapy; DNA methylation; Glioblastoma; Chemotherapy; Methylation; Cancer research; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007267152,0.0004165766,0.001788928,0.0004406583,0.00007111727,0.00004603545,0.0001877606,0.0002404044,0.00009708307],"category_scores_gemma":[0.0005814068,0.0001968781,0.0003632652,0.001147501,0.0002781025,0.00008320307,0.0001021661,0.0003407116,0.00002184029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004366024,"about_ca_system_score_gemma":0.0002781625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646526,"about_ca_topic_score_gemma":0.008299069,"domain_scores_codex":[0.9961481,0.001188961,0.001138481,0.0007106557,0.0004154273,0.0003983818],"domain_scores_gemma":[0.9956446,0.003062034,0.000391033,0.0006394714,0.0001346148,0.0001282835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04744128,0.01183021,0.4736174,0.0002407922,0.00571636,0.004114457,0.009039516,0.0003679863,0.0773679,0.0003542864,0.0009678811,0.3689419],"study_design_scores_gemma":[0.2349925,0.1005596,0.3560656,0.002334127,0.01581489,0.0003388261,0.0009936074,0.006144716,0.2428075,0.0017787,0.03689978,0.0012701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912515,0.001040467,0.000001378047,0.00432071,0.0002999517,0.002435638,0.0001117686,0.00004143754,0.0004971031],"genre_scores_gemma":[0.9984964,0.0003703045,0.00005682244,0.0004219567,0.0000837621,0.0004574804,0.00002379161,0.00004837002,0.00004116066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3676718,"threshold_uncertainty_score":0.8028455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213492661300165,"score_gpt":0.2716421380202313,"score_spread":0.2595072114072297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}