{"id":"W4399973113","doi":"10.1093/neuonc/noae108","title":"No benefit from TMZ treatment in glioblastoma with truly unmethylated <i>MGMT</i> promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly glioblastoma patients","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Canadian Cancer Society Research Institute; Deutschen Konsortium für Translationale Krebsforschung; Universität Zürich; Centre Hospitalier Universitaire Vaudois; Umeå Universitet; Linköpings Universitet; Université de Lausanne; European Organisation for Research and Treatment of Cancer; Deutsches Krebsforschungszentrum","keywords":"Temozolomide; Methyltransferase; Oncology; Medicine; Internal medicine; Clinical trial; O-6-methylguanine-DNA methyltransferase; Population; Radiation therapy; DNA methylation; Glioblastoma; Chemotherapy; Methylation; Cancer research; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04818769,0.002497066,0.008662983,0.003928175,0.0003692628,0.002408816,0.001325391,0.001071963,0.001821042],"category_scores_gemma":[0.05276281,0.0008129834,0.02813255,0.003128173,0.0006787356,0.0008634051,0.001865517,0.001603272,0.0003050911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001253798,"about_ca_system_score_gemma":0.002265043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007586534,"about_ca_topic_score_gemma":0.01021447,"domain_scores_codex":[0.9484059,0.03331672,0.006671783,0.005444719,0.004823681,0.001337226],"domain_scores_gemma":[0.9701465,0.01859762,0.005247708,0.00326052,0.00224882,0.0004988245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.06496483,0.00012788,0.1150455,0.01782723,0.7282052,0.0005917462,0.0003994482,0.01237141,0.00509892,0.0007946506,0.008695167,0.04587797],"study_design_scores_gemma":[0.0109184,0.005616555,0.3121326,0.002669134,0.6133916,0.0007856789,0.0003376598,0.008158875,0.003495536,0.001687005,0.04058506,0.0002218369],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6252955,0.2597686,0.03260397,0.002561294,0.00189969,0.005199963,0.06624295,0.0006211658,0.005806915],"genre_scores_gemma":[0.9511065,0.008224455,0.01340557,0.00130911,0.0003913404,0.00323823,0.02019599,0.0002876028,0.001841184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04818769,"threshold_uncertainty_score":0.2548439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213492661300165,"score_gpt":0.2716421380202313,"score_spread":0.2595072114072297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}