{"id":"W4399973654","doi":"10.1002/prp2.1225","title":"Teaching an old drug new tricks: Regulatory insights for the repurposing of hemin in cardiovascular disease","year":2024,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Saint John Regional Hospital; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Hemin; Medicine; Drug repositioning; Context (archaeology); Biopharmaceutical; Repurposing; Intensive care medicine; Drug; Pharmacology; Disease; Dosing; Drug development; Pharmacy; Adverse effect; Internal medicine; Heme; Biotechnology; Family medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02881218,0.0005132239,0.0007793746,0.005322591,0.003232243,0.01084708,0.001832017,0.005453246,0.005708911],"category_scores_gemma":[0.04429947,0.0004125713,0.0009667829,0.004353438,0.009731907,0.01064711,0.003371957,0.007391768,0.001241957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006883794,"about_ca_system_score_gemma":0.02019717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009476515,"about_ca_topic_score_gemma":0.01767826,"domain_scores_codex":[0.9874278,0.005072997,0.0009969918,0.001265175,0.004240904,0.0009961363],"domain_scores_gemma":[0.9414067,0.04057918,0.004636455,0.002434653,0.008846624,0.002096345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003354371,0.0004186211,0.006990066,0.003409507,0.00005704266,0.003817553,0.0105498,0.001090795,0.005705223,0.2906091,0.0732188,0.6037981],"study_design_scores_gemma":[0.00004650093,0.0002439693,0.006315279,0.005640316,0.0000947496,0.00248905,0.005228184,0.001040363,0.003291919,0.09784538,0.8776574,0.0001068878],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02803609,0.386356,0.01818569,0.463896,0.003087026,0.0002351339,0.0006933211,0.0001908379,0.09931993],"genre_scores_gemma":[0.4027256,0.4290195,0.03111607,0.1141492,0.008957488,0.0002680801,0.0008933448,0.000164412,0.01270628],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02881218,"threshold_uncertainty_score":0.1523752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03818132580338167,"score_gpt":0.3854963591912483,"score_spread":0.3473150333878666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}