{"id":"W4399973654","doi":"10.1002/prp2.1225","title":"Teaching an old drug new tricks: Regulatory insights for the repurposing of hemin in cardiovascular disease","year":2024,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Saint John Regional Hospital; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Hemin; Medicine; Drug repositioning; Context (archaeology); Biopharmaceutical; Repurposing; Intensive care medicine; Drug; Pharmacology; Disease; Dosing; Drug development; Pharmacy; Adverse effect; Internal medicine; Heme; Biotechnology; Family medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002226839,0.0001621881,0.0002282667,0.0002435638,0.0001924831,0.00004190209,0.0003930577,0.00009258444,0.00002192578],"category_scores_gemma":[0.0002665664,0.000127272,0.0002986332,0.0002667853,0.0003195104,0.00002093753,0.0001595869,0.0004838472,0.00000194743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065202,"about_ca_system_score_gemma":0.000555856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003825948,"about_ca_topic_score_gemma":0.00005386007,"domain_scores_codex":[0.9976212,0.0006878592,0.0002292885,0.0006951092,0.000326542,0.0004399745],"domain_scores_gemma":[0.9988596,0.0002464513,0.00002676355,0.000500733,0.0001470368,0.0002193902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006943084,0.0002323315,0.0002612903,0.0001385608,0.0009560999,0.00006519452,0.007588261,0.0004295136,0.9582333,0.001645714,0.01265289,0.01710255],"study_design_scores_gemma":[0.002335102,0.0005071928,0.002295323,0.0001159169,0.0003734047,0.00001804196,0.01584209,0.005732829,0.6498157,0.002218767,0.3202234,0.0005222476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8492122,0.1480068,0.0003283874,0.0009631207,0.0001865923,0.0007940931,0.00001340214,0.00002271455,0.0004727367],"genre_scores_gemma":[0.9942087,0.001940114,0.0001338979,0.00007153389,0.001029982,0.0002161347,0.00001587359,0.00003949545,0.002344297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3084176,"threshold_uncertainty_score":0.5190003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03818132580338167,"score_gpt":0.3854963591912483,"score_spread":0.3473150333878666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}