{"id":"W4399980559","doi":"10.1016/j.nicl.2024.103635","title":"Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Centre d'Imagerie BioMédicale; Centre Hospitalier Universitaire Vaudois; Université de Genève; Alzheimer's Association; Hôpitaux Universitaires de Genève; Eisai; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Northern California Institute for Research and Education; University of Southern California; Pfizer; Biogen; BioClinica; Meso Scale Diagnostics; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Université de Lausanne; Novartis Pharmaceuticals Corporation; École Polytechnique Fédérale de Lausanne; Bristol-Myers Squibb; National Science Foundation","keywords":"Apolipoprotein E; Dementia; Neuroimaging; Centrality; Disease; Functional magnetic resonance imaging; Neuroscience; Clinical Dementia Rating; Psychology; Alzheimer's disease; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002211703,0.000252067,0.0005084001,0.00004328845,0.0004896496,0.0001856321,0.0003147048,0.00009825847,0.000102851],"category_scores_gemma":[0.01753126,0.0001846181,0.0004777788,0.0004441135,0.002243496,0.0002990009,0.0006116983,0.001351291,0.0001291853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001760993,"about_ca_system_score_gemma":0.0001319286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001200242,"about_ca_topic_score_gemma":0.00001951434,"domain_scores_codex":[0.9954864,0.001226344,0.001157785,0.001193702,0.0004577951,0.0004779483],"domain_scores_gemma":[0.9555567,0.04336895,0.0002185277,0.0005333186,0.00003913481,0.0002833953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005921444,0.0007254916,0.8376892,0.00008054928,0.0003739372,0.000436068,0.0002073391,0.00009182099,0.0004460641,0.005490956,0.131279,0.0225875],"study_design_scores_gemma":[0.0003316074,0.0001781436,0.9483301,0.00004114346,0.0001989751,0.00001875249,0.00002305759,0.0004450414,0.0001990384,0.005047966,0.0450189,0.0001672807],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94382,0.0006809652,0.0004067362,0.04764218,0.005882626,0.0004967921,0.0003376313,0.000248792,0.000484259],"genre_scores_gemma":[0.9924729,0.0003272007,0.00004539373,0.004013217,0.002780529,0.00002303547,0.0000126937,0.00003461986,0.0002904288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106409,"threshold_uncertainty_score":0.9907445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.248539484327061,"score_gpt":0.4442861354738099,"score_spread":0.1957466511467488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}