{"id":"W4399980559","doi":"10.1016/j.nicl.2024.103635","title":"Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Centre d'Imagerie BioMédicale; Centre Hospitalier Universitaire Vaudois; Université de Genève; Alzheimer's Association; Hôpitaux Universitaires de Genève; Eisai; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Northern California Institute for Research and Education; University of Southern California; Pfizer; Biogen; BioClinica; Meso Scale Diagnostics; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Université de Lausanne; Novartis Pharmaceuticals Corporation; École Polytechnique Fédérale de Lausanne; Bristol-Myers Squibb; National Science Foundation","keywords":"Apolipoprotein E; Dementia; Neuroimaging; Centrality; Disease; Functional magnetic resonance imaging; Neuroscience; Clinical Dementia Rating; Psychology; Alzheimer's disease; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000603884,0.0002298049,0.0002051276,0.00149697,0.0002146817,0.0004007087,0.0001697762,0.0001757086,0.001614207],"category_scores_gemma":[0.003967362,0.00007998688,0.0002404692,0.001198549,0.0002535637,0.0003964182,0.0003727365,0.0002061512,0.00009786386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835355,"about_ca_system_score_gemma":0.0002310108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004609406,"about_ca_topic_score_gemma":0.006637505,"domain_scores_codex":[0.9997354,0.00008710453,0.00001783893,0.00008791103,0.00003306547,0.00003863759],"domain_scores_gemma":[0.997978,0.001178649,0.0004593242,0.0001143583,0.0001419771,0.0001277611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008381521,0.00009983101,0.9415789,0.00009304102,0.0005583579,0.0002679393,0.0005503345,0.009446422,0.01388735,0.001989658,0.0009686751,0.02972138],"study_design_scores_gemma":[0.00001203698,0.000108521,0.9672659,0.00001020322,0.0001126048,0.0003929334,0.0001841337,0.02672487,0.0009484662,0.003722092,0.0005024705,0.00001559541],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957496,0.000136711,0.002959857,0.00005512587,0.000004201335,0.000006890677,0.0005671334,0.00002157599,0.000498879],"genre_scores_gemma":[0.99884,0.00003326795,0.0007143982,0.000003470404,0.000004103981,0.000004228061,0.0003203667,0.000003016223,0.00007723944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004609406,"threshold_uncertainty_score":0.009165168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.248539484327061,"score_gpt":0.4442861354738099,"score_spread":0.1957466511467488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}