{"id":"W4399984012","doi":"10.1002/2211-5463.13853","title":"Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase","year":2024,"lang":"en","type":"article","venue":"FEBS Open Bio","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Farnesyl pyrophosphate; Mevalonate pathway; Allosteric regulation; Geranylgeranyl pyrophosphate; Biochemistry; Enzyme; Pyrophosphate; Chemistry; Kinase; ATP synthase; Farnesyl diphosphate synthase; Biology; Biosynthesis; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758049,0.0002820938,0.0001734082,0.0001264646,0.0000847694,0.000195648,0.0001880587,0.0001785578,0.001302436],"category_scores_gemma":[0.0001661146,0.00007594191,0.0001448287,0.00008231972,0.0001402315,0.00009563727,0.0001329421,0.00037167,0.0002586621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645812,"about_ca_system_score_gemma":0.0001990254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004810221,"about_ca_topic_score_gemma":0.001033178,"domain_scores_codex":[0.9999079,0.00002492237,0.000008041647,0.00001789538,0.00001912424,0.00002228552],"domain_scores_gemma":[0.9999449,0.00002532233,0.000009884886,0.000006340787,0.000005558165,0.000007931088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002285088,0.00009478054,0.0001294522,0.00006235118,0.000009455306,0.00003298379,0.00001673403,0.0003999479,0.9946737,0.0002130533,0.00006991924,0.004068995],"study_design_scores_gemma":[0.00006555678,0.0009934669,0.0006713059,0.000009407422,0.00001698042,0.0001403775,0.00001355033,0.001050128,0.9934842,0.0000562382,0.003493116,0.000005730539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824079,0.007085822,0.005151799,0.0002070276,0.00007383226,0.00009969708,0.0002879982,0.00009942496,0.004586602],"genre_scores_gemma":[0.9918509,0.002911509,0.003308743,0.00007721963,0.00001612975,0.00004386536,0.0002574199,0.00001344169,0.001520759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302436,"threshold_uncertainty_score":0.00435704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245077225121384,"score_gpt":0.2632683902205346,"score_spread":0.2508176179693208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}