{"id":"W4399997020","doi":"10.1101/2024.06.20.599895","title":"Sex and Disease Regulate MHC I Expression in Human Lung Epithelial Cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Major histocompatibility complex; Biology; MHC class I; Immunology; CD8; Downregulation and upregulation; Immunosurveillance; Idiopathic pulmonary fibrosis; MHC class II; Lung; Immune system; Medicine; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499833,0.0001021016,0.0001495087,0.0002644256,0.0002325688,0.0004946277,0.00008803287,0.0001694337,0.002389254],"category_scores_gemma":[0.000257016,0.00008385935,0.0002065607,0.0002744489,0.0001422394,0.0001285232,0.0002372638,0.000249411,0.0006200995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001246439,"about_ca_system_score_gemma":0.0001216406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000546112,"about_ca_topic_score_gemma":0.0006726143,"domain_scores_codex":[0.9997931,0.00002732964,0.00001390877,0.00006934801,0.00004876446,0.00004754873],"domain_scores_gemma":[0.9998816,0.0000232825,0.00003933921,0.00001271095,0.00002723202,0.00001582594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004388212,0.00005001588,0.04650564,0.000196625,0.00004279097,0.0004133222,0.0002809435,0.00009649534,0.9347853,0.0001447357,0.0005032055,0.01654207],"study_design_scores_gemma":[0.00003634868,0.0006034443,0.6487583,0.00007019607,0.0001082897,0.002878028,0.001576734,0.001581664,0.3259478,0.0003541328,0.01804188,0.00004313961],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902406,0.005129342,0.001276667,0.0001320855,0.00005899544,0.00002044675,0.001499047,0.00003186376,0.001611009],"genre_scores_gemma":[0.9954569,0.001305017,0.0004910768,0.0001206199,0.00002272077,0.00002977117,0.001030847,0.00001299142,0.001530132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002389254,"threshold_uncertainty_score":0.007992864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008969866438730635,"score_gpt":0.2127805459474019,"score_spread":0.2038106795086712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}