{"id":"W4399997020","doi":"10.1101/2024.06.20.599895","title":"Sex and Disease Regulate MHC I Expression in Human Lung Epithelial Cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Major histocompatibility complex; Biology; MHC class I; Immunology; CD8; Downregulation and upregulation; Immunosurveillance; Idiopathic pulmonary fibrosis; MHC class II; Lung; Immune system; Medicine; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005499819,0.0006744562,0.0007230284,0.0004182374,0.0002616206,0.000133615,0.0004548052,0.0009767385,0.00008462938],"category_scores_gemma":[0.0001128864,0.0006683492,0.0001537195,0.0002635318,0.000290141,0.0000966511,0.001255263,0.001494839,0.0002281381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773213,"about_ca_system_score_gemma":0.0005593619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006223581,"about_ca_topic_score_gemma":0.000004225129,"domain_scores_codex":[0.9968503,0.0003468576,0.0006157543,0.001352238,0.0001006217,0.000734219],"domain_scores_gemma":[0.9982613,0.00006329122,0.0002421593,0.001112409,0.0001243532,0.0001964757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007959858,0.0001284172,0.001418362,0.0009324279,0.0001085112,0.0001678533,0.00006973473,0.00001345214,0.9944429,0.0006118093,0.002024693,0.00000217597],"study_design_scores_gemma":[0.0008923869,0.0000415083,0.01477332,0.001145102,0.0001573669,3.997883e-8,0.000006180999,0.00003535948,0.9672635,0.00006556622,0.01479233,0.0008273469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847906,0.006641117,0.00006714123,0.00008420945,0.002693656,0.000726133,0.004576489,0.0003877931,0.00003292189],"genre_scores_gemma":[0.9985013,0.0004731456,0.0001285456,0.0001082159,0.0003032598,0.0001456172,0.000003989133,0.0001349111,0.0002010003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02717947,"threshold_uncertainty_score":0.9995767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008969866438730635,"score_gpt":0.2127805459474019,"score_spread":0.2038106795086712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}