{"id":"W4399999726","doi":"10.1073/pnas.2403777121","title":"Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McGill University","funders":"Canadian Institutes of Health Research; Louise and Alan Edwards Foundation; Agence Nationale de la Recherche; McGill University","keywords":"Parvalbumin; Tonic (physiology); Inhibitory postsynaptic potential; Allodynia; Chronic pain; Neuroscience; Medicine; Hyperalgesia; Biology; Internal medicine; Nociception; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059087,0.0001350076,0.000204908,0.0001103199,0.0001231413,0.0003441827,0.0002521093,0.0001693578,0.0007037729],"category_scores_gemma":[0.0001724753,0.00008664775,0.0001142136,0.00007413164,0.0003998939,0.0002532573,0.0001981715,0.0006544093,0.00009518835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004289622,"about_ca_system_score_gemma":0.0001919888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007315048,"about_ca_topic_score_gemma":0.001529014,"domain_scores_codex":[0.9998684,0.00001049173,0.000007768307,0.00001972208,0.00003314233,0.00006045082],"domain_scores_gemma":[0.9998884,0.00001395568,0.00004172414,0.0000084243,0.00001318408,0.00003422201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000134417,0.00002397277,0.0005315911,0.00002884567,0.000004394576,0.00003787453,0.00001129059,0.00009268652,0.9957052,0.0001244799,0.00003164915,0.003273675],"study_design_scores_gemma":[0.00009032795,0.001112777,0.06719696,0.00003423464,0.00006606657,0.000542688,0.0001231145,0.007464144,0.9200699,0.0006482107,0.002638204,0.00001334318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994328,0.0009089234,0.003364034,0.0001375158,0.00003293298,0.000008195549,0.00005942637,0.00007486278,0.001086063],"genre_scores_gemma":[0.9978566,0.0004218538,0.000836592,0.00005107193,0.000008898879,0.000009635508,0.00003516964,0.00001347997,0.0007666062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007315048,"threshold_uncertainty_score":0.003112316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634592168324266,"score_gpt":0.324293270249197,"score_spread":0.2779473485659543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}