{"id":"W4400002364","doi":"10.1016/j.cccb.2022.100073","title":"FIBRINOGEN ACTIVATES MICROGLIA AND DRIVES EXTRACELLULAR VESICLE MEDIATED PROPAGATION OF PRO-INFLAMMATORY SIGNALING","year":2024,"lang":"en","type":"article","venue":"Cerebral Circulation - Cognition and Behavior","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Microglia; Extracellular vesicles; Cell biology; Fibrinogen; Extracellular; Extracellular vesicle; Inflammation; Chemistry; Neuroscience; Immunology; Biology; Microvesicles; Biochemistry; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298747,0.000124179,0.0001604648,0.00008319433,0.0001158943,0.00004596826,0.00002962787,0.0001325916,0.0002775451],"category_scores_gemma":[0.00001904921,0.0001141089,0.00009273677,0.00008423554,0.0001294445,0.0002198181,0.00002189618,0.00008758016,0.00002609258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001388552,"about_ca_system_score_gemma":0.00002815718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005487338,"about_ca_topic_score_gemma":6.820133e-7,"domain_scores_codex":[0.9992409,0.00009756965,0.0002308257,0.0002538293,0.00005326402,0.0001235883],"domain_scores_gemma":[0.9997035,0.00004211482,0.00007022459,0.00008060579,0.00007476705,0.00002879234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001724428,0.00005795,0.01901336,0.0001248958,0.00009491566,0.000002388667,0.0002445625,0.000001571049,0.9632446,0.000244466,0.000008630156,0.01694546],"study_design_scores_gemma":[0.0006916485,0.00004793118,0.3409063,0.0001804758,0.0005289651,0.00003152596,0.0003354338,0.00007107705,0.65667,0.000128227,0.0002316772,0.0001766637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890545,0.009924751,0.0003085961,0.00002180736,0.0001097239,0.0004007752,0.00005102884,0.00009170415,0.00003710721],"genre_scores_gemma":[0.9993701,0.00008475369,0.00003705377,0.00001007824,0.00002754354,0.00005643776,0.0003299381,0.00001684797,0.00006726213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3218929,"threshold_uncertainty_score":0.4653224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754346068135721,"score_gpt":0.231753482997065,"score_spread":0.2142100223157078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}