{"id":"W4400002364","doi":"10.1016/j.cccb.2022.100073","title":"FIBRINOGEN ACTIVATES MICROGLIA AND DRIVES EXTRACELLULAR VESICLE MEDIATED PROPAGATION OF PRO-INFLAMMATORY SIGNALING","year":2024,"lang":"en","type":"article","venue":"Cerebral Circulation - Cognition and Behavior","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Microglia; Extracellular vesicles; Cell biology; Fibrinogen; Extracellular; Extracellular vesicle; Inflammation; Chemistry; Neuroscience; Immunology; Biology; Microvesicles; Biochemistry; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002741074,0.0004485653,0.0003424638,0.0004603673,0.0004265694,0.0008823205,0.0002085814,0.0007108939,0.002794468],"category_scores_gemma":[0.0004019802,0.0002062283,0.0005689662,0.0001898452,0.0001972815,0.0003592402,0.0005162558,0.0008688407,0.001088722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007201885,"about_ca_system_score_gemma":0.0004881919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272687,"about_ca_topic_score_gemma":0.002253945,"domain_scores_codex":[0.9994617,0.0001354679,0.00003022088,0.00005214156,0.0001295194,0.0001908817],"domain_scores_gemma":[0.9998491,0.00002548113,0.00003499452,0.00001809787,0.00003045066,0.00004186115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006781052,0.00006878498,0.0009469971,0.00007914029,0.00003110469,0.0004453867,0.0001176736,0.0001600652,0.9909621,0.001005393,0.0004986292,0.005006663],"study_design_scores_gemma":[0.000215881,0.001195999,0.07193077,0.0001135634,0.0001087715,0.001700497,0.0009595698,0.00481935,0.9057776,0.003056314,0.01006984,0.00005187883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840835,0.003641367,0.004309539,0.0008945738,0.0001547339,0.00005049421,0.0004310733,0.00008597795,0.006348768],"genre_scores_gemma":[0.9931071,0.001297375,0.001387733,0.0001745116,0.00006285275,0.00004059642,0.0003187856,0.00001491387,0.003596058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002794468,"threshold_uncertainty_score":0.009348452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754346068135721,"score_gpt":0.231753482997065,"score_spread":0.2142100223157078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}