{"id":"W4400004445","doi":"10.1128/spectrum.00959-24","title":"Construction and immunogenicity of SARS-CoV-2 virus-like particle expressed by recombinant baculovirus BacMam","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute on Deafness and Other Communication Disorders; National Institute of Allergy and Infectious Diseases; Ministry of Agriculture - Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Innovation Saskatchewan; National Institutes of Health","keywords":"Immunogenicity; Virology; Recombinant DNA; Coronavirus disease 2019 (COVID-19); Baculoviridae; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Virus; 2019-20 coronavirus outbreak; Recombinant virus; Virus-like particle; Computational biology; Genetics; Medicine; Gene; Antibody; Outbreak; Spodoptera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003020407,0.0002151375,0.0004359285,0.0001331106,0.00008051452,0.00003206413,0.0001383925,0.0002255881,0.00005276483],"category_scores_gemma":[0.00004227283,0.000182189,0.0001346386,0.0002976438,0.0006165419,0.00008308529,0.0001298385,0.00035439,0.0001458146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001007221,"about_ca_system_score_gemma":0.0001497782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005821552,"about_ca_topic_score_gemma":0.00009491432,"domain_scores_codex":[0.9984098,0.0001125979,0.0003992989,0.0005198821,0.00008128338,0.0004771514],"domain_scores_gemma":[0.9993841,0.0001125863,0.00006347388,0.0003671231,0.00004403219,0.00002867917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004666801,0.0001393375,0.005620975,0.0001228127,0.0001937484,0.00004968476,0.0001373166,1.412375e-8,0.9865769,0.0002580618,0.004186557,0.002247953],"study_design_scores_gemma":[0.001064876,0.0004318734,0.0003328038,0.00006560557,0.00006452606,0.0004417463,0.00005453962,0.00004181353,0.8243518,0.0003616865,0.1726443,0.0001444148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907592,0.006831252,0.0001225079,0.0008719648,0.0005218409,0.0003391737,0.0001024897,0.0001118208,0.0003397344],"genre_scores_gemma":[0.9954028,0.000166778,0.0001923824,0.004025912,0.00006194547,0.00002139803,0.00002464185,0.00003247958,0.0000716416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1684578,"threshold_uncertainty_score":0.7429453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462887810998385,"score_gpt":0.3068230568967185,"score_spread":0.2821941787867346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}