{"id":"W4400004445","doi":"10.1128/spectrum.00959-24","title":"Construction and immunogenicity of SARS-CoV-2 virus-like particle expressed by recombinant baculovirus BacMam","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute on Deafness and Other Communication Disorders; National Institute of Allergy and Infectious Diseases; Ministry of Agriculture - Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Innovation Saskatchewan; National Institutes of Health","keywords":"Immunogenicity; Virology; Recombinant DNA; Coronavirus disease 2019 (COVID-19); Baculoviridae; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Virus; 2019-20 coronavirus outbreak; Recombinant virus; Virus-like particle; Computational biology; Genetics; Medicine; Gene; Antibody; Outbreak; Spodoptera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004146719,0.000449846,0.0002349314,0.0002595796,0.0001852459,0.0003723873,0.0003482817,0.0004209276,0.0004760637],"category_scores_gemma":[0.0003250579,0.000156155,0.0004134001,0.0002832321,0.0002187112,0.0002691415,0.0002493369,0.0006136374,0.0003185722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004989072,"about_ca_system_score_gemma":0.0001754027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005100276,"about_ca_topic_score_gemma":0.0002992504,"domain_scores_codex":[0.9997615,0.00006011232,0.00003006486,0.00004115458,0.00007721181,0.00002997377],"domain_scores_gemma":[0.9998976,0.00001917134,0.00002610757,0.00001757617,0.0000241107,0.00001549288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000532267,0.00005693045,0.0002050911,0.00003337809,0.000008012192,0.00004323402,0.00002424843,0.0001465328,0.998733,0.0001017928,0.00002365789,0.0005710064],"study_design_scores_gemma":[0.00004157378,0.0007667401,0.002659429,0.000009324081,0.00003256741,0.0002369037,0.00002983225,0.001841693,0.9916179,0.00006823021,0.002687183,0.000008624073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935704,0.0007584538,0.004397485,0.00007298025,0.00004348683,0.0001152399,0.000292444,0.00003314746,0.0007162495],"genre_scores_gemma":[0.9850743,0.0006377727,0.009377233,0.0000895802,0.00002591724,0.0001186472,0.002548684,0.00002826489,0.002099577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005100276,"threshold_uncertainty_score":0.00361985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462887810998385,"score_gpt":0.3068230568967185,"score_spread":0.2821941787867346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}